Major Histocompatibility Complex (MHC)

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MajorHistocompatibilityComplex
(MHC)
Atifa Ambreen
M. Phil, Microbiology
Government College University, Faisalabad

Major Histocompatibility
Complex
Themajorhistocompatibilitycomplex(MHC)isasetofgenes
thatcodeforcellsurfaceproteinsessentialfortheacquired
immunesystemtorecognizeforeignmoleculesinvertebrates,
whichinturndetermineshistocompatibility.
•OnceaT-cellresponsehasbeeninitiated,macrophagesandB
cellsthathavetakenupspecificantigenalsobecometargets
forarmedeffectorTcells.
•Peptidesfromintracellularpathogensthatmultiplyinthe
cytoplasmarecarriedtothecellsurfacebyMHCclassIand
MHCclassIIandCD4Tcellsrespectively.

Continued…
•TheseTcellscandifferentiateintotwotypes
ofeffectorTcells,calledTH1andTH2.
•Pathogensthataccumulateinlargenumbers
insidemacrophageanddendriticcellvesicles
tendtostimulatethedifferentiationofTH1
cells,whereasextracellularantigenstendto
stimulatetheproductionofTH2cells.

Antigen Presenting Cells (APCs)
•Dendriticcells
• Macrophages
• B cells
APCpresentsMHCclassII(MHC-II)specific
forCD4Tcellswhileallnucleatedcellshave
MHCclassI(MHC-I).