MANEJO DE HIPERGLUCEMIA EN PACIENTES HOSPITALIZADOS R2 MEDICINA INTERNA RAFAEL LOPEZ VARGAS
15 14 12 w õ 11 10 Distribution Glucose Values í the National Heart Care Patient Cohort 50 100 150 200 250 300 350 400 450 500 550 600 Admission Glucose (mg/dL) Kosiborod M et al. Circulation. 2009;119:1899- 1907
CUAL DEBE SER EL MANEJO DE UN PACIENTE CON DIABETES MELLITUS TIPO 2 DURANTE UNA HOSPITALIZACIÓN POR OTRA CAUSA ?
Basal/bolo 130 Pocientes insulins Dias de hospi alización Deas de hospi alización 5.2 dna
AO 18 160 140 100 7 8 Days of Therapy Ftgnre I—Changes in blo nd glucose conrcntrntions in yatietits treated with glargine plus gfu- lisinc and with SSI . *P 0.0J ; TP < 0.d5. 10
> ae recomienoo ia uriiizocion oe esouetnas oasøu QUE ES DIAGNOSTICADO CON DM 2 DURANTE UNA HOSPITALIZACION FOR OTRA CAUSA*
Cl i n i c a I C a r e / E d u c a I i o n / N u I r i I i a n /P s y c h a s a c i a I R e s e a z < h Basal- Belus W!t h a Basal Plus Correction Znsul!n Rep!nsen fer ¢he Hosp!tml Manapemen0 ef Me4!caI an4 Surp!cal !a& Patients W!eh Basal Plu s Txial D*zwSxiw,wo' Cozoronire Nxmou, no' critically ill patients have reported that improvement of glycemñ control reduces hospital complications ( I, hospital stay, and mo oality (6— 8). In patients with T2D admit red to general medicine and surgery services, tecent Tdndoniized, controlled trials Ave shown that treat- ment with a heal- bolus regimen results
160 220 100 T80 160 140 Random- Breakfast VBasal Bolus OBasal Plus g ; Day of Treatment Lunch OBasal Plus Dinner Time of Day Bedtime
N H 12— 20 hours detemir - 6- 23 hours (dose dependant) glargine - 20- 26 hours Hours Note: action cuves axe approxi ations for illus rative pu poses. Ac ua patient 15 18 17 18 19 20 21 esponse will vas.
200 180 160 140 120
de hipoglucemio, fueron Simïlores en los 2 grupos: VO NPH + Regular = Detemir + Asport
Omitir medicociones oroles o inyectobles diferentes a la insulins Administror la mitod de la dosis usual de NPH o un 70% del Si el pociente utilize insulins premezclodo odministror la
RABBIT TRIAL Glargine + Glulisine N= 104 Half as glargine once daily Half as glulisine before meals 211 PACIENTES CON DIABETES TIPO 2 SOMETIDOS A CIRUGIA GENERAL RANDOMIZACION Sliding scale insulin SSRI) N= 107 Group 2: 4 times/day for BG x14O mg/dl
220 180 140 120 B 220 200 180 160 140 120 Duration of Treatment (days) Lunch Breakfast Umpierrez G E et al. Dinner t ) Bedtime