Manufacture of pharmaceutical preparations

Hospital Pharmacy Pharm D 4th year

1. Peepeaobi ony :

~ lage 4 small volume Parenterals

o) Stele der

oral om odmmauterel in a bo
india body Has ma

cra mean co oe

puertos) prposohos au tele prepara chews

patrie one, or more achire ingredient fm ode

ty machos «ion toca u dl

qu me perd alter sigle doie [ruthtdose

container >
> Pountods << small volume posenterals
— Oroge volme prunteals.

y srl vobune_paurtaal:
intended 47
He as containing oom)

Lg shute produ pourtaal we Hal o
pecked 10 centaines ond abe

or les an known os SVP

5) Lage clame Postes Li:
prov ustended fpr gaurtual we

un vend volume era

om au know

— à seule

rat a wall supplied
greater Shan room) % 2 hs

os ENP
Advantage
tn be gun À patients uno auch take Aus vel
~ Ron, Fink pus meabetue can Pe arde
saga us

rayé anto

= Page cao de ane

2. = Can be gven de untonitiou akents

— Day action can be pedoged by modihging ta
Aomdahon

Doadvantoger:

Rain and Aus damage, af due Ste A jedi
—Reguric trained persons to administer a duo

- Det do Se Mu pation 3 cohen cvadoie à givey
— espere sand costly
= Require special equipment, Amen do prepa and
administer Hi dur

Fermbahen _ Pela

Y? Vide!

+ gens she Wy Non-aquios wh
~ wri — corne utd nor aq

ra pe komlon Veh au oily & alchoa
WEE fee Hom dusdved air Co poh is most commonly
ured as vehide =
3, Péjoors

~sobbaligng agent

— Suapending » emdispyiog and webing agur
—Tomoty factors

= stalalizas

= ufpanag age

3. gb Mo Fou
Hache Punts sale schon > Ag
vehele L
valuation
Labelling & packing

temes los specific imemg cyte whos

canes, ade placed tnd laminas alas

ond Hrmigfly cleaned ung due weba

pued toda + WET

dun Weigh equal quantı hes & vou

sua ond dranbered do mag tal
+

gun cduent ta aded and he mia o

steed sun all solutes dimclve copla

led fo remove

y
Ru formed sahen & y
unkscher matter

+
Filing u ced “ou und)
ean ed containers, on “transfered do

Qumantıne arta jor sheshgahion proces

J oseptic. condition

fled amples ond vals au does 19

irs area (quarantine ata)

ES
Packaging and Labeling y pasına-

4. = label’ should contain Name preperation
27

& prepaation ; Mfg Lie No - , DOM , POE, ds
Ye

A A

address -

D Mankachw« 0: Vstaahte oinbents,

and Cotos

Seconda Sarah” prepaith om, mean) for
extemal application Jo skin Cat) mos membrane

a _ Non medicated ointments
AL O linda! odia
PNM: St corkains only animent: bases, does mt
contain any meltament

EX! Simple vidmert and yasakfın ciment

MO: GH corkerins only redicoments «whith may disched,

Suapensed ard emulsified in Ku cinhment base

Ex: Gulf bites, boric atıd ointment
Memhachuing “os cickmenty: %) Fahsahion method
2) Roïion meld
Dembbaion melted:
%) Cemitad veachon
SK 6 mainly wed fy He pegado
& sel Dh in small scale indashy

=D bay manly tao mehhade 1) Drhmeat db
1) Moor & Desbla method

9 Fehuakion melted:

5. Finely powder Ea medicament and place
wa qa ciment le

ego ee quortihy be 6h cient hose
and Yeap om one dient past 4 dab
que a potion Gp base cd abod shes
de volume A du ond levigate + toil He,
hdp & ocio
ex: Sulphan ointmrt“
ator on paille method 1 aed or aga quests

9} Bain me method!

oq Hous mdhod malt À substance with highest rio

por old by addition of substarces by desreosiny ord

4 dling point A;

Gs meted mam incorporate “ke melina! ond

A A ws ol dun A

Shey Apowughly
Grant Jamed
Ex: tedsim de ont?
> tmbion mato
Ol sane om med in a Cra dub on
vodabalb at 30°C
+
taba sahbte sullence ou heed sh
on waterbath of HO°C

6. +
Gulable emulsifying Agent 1 dusdved m ein
in agputous (or) in oily Phare

y
bla bol phases veathes same emperahis ,

aquucovo pha, à sbaly added dr He oily
phase a corlinaosa otero whl
pau eme tal and senmolid

Y amical veachten: ointment u.prepered belsoeen
Chemical seadhion 4 medicament and ont more ingredant
9 x base

Cream,

Grams ox viscous emdbions 4 semischd

combuleney intended fox “external eppreation +
Hu skin (oy) mucous membrane.

eig,

~ oily creams containing solo type Oy emulsifying aut
eq Wool tot, alcohol. a acids
hope creat conning Of Aye 6, eying ot
Eg? Emi vous acd eter
D cold Creams
Mak Ha wer ard asa tipa parado 47
heal He mix 30°C
+

olw Loggueous creams)

blo Loly creoms)

7. Dusolve ta boat In water ok 5%
aod weht Ya won with continuous Shrsing
3
ld
cod He min of HO" ard ada padune and

prasuches

L
Gand Ma creom wm while bot

9) Tanning Cream

ego ts eur quan
and dll gaben in ch

wahr sduble trgedents to wer
ra hea of BE

Mes & Share add
inadısh and heat ab we

Gala He
Check Ha temparchas ah nes on
y

he aqueos plow

Furst Hu oly poe +
a N out emo)

gmall proportions wills Lhomogen
continuos img until Me tongo emulsion

ws poe

Renore Ha dina sak Aion “heatieg and cool
Lo Ha won Jomperahaae
ids: Legado aut mmephane dere em » which
incas Hu mucha GF active phaarnacerhical vue

along wth exapienls
a ion [ton senption
E es = dat

obe preaichion = Angie mu
Navel 7
= Meaty wesh

8. Re prpaation 4 tuna inclde sm and vou iy
nt operation and require Les Jermdalon cpu)

= pasat ide ng
ghz y sing «ising + cdashyertion [tico hg

and packing +

Roo mateuals cd a
aide - to Neo
Sale - gddentin-
Stebaliger - 207"
‘praayolves~ Raabened
Mucostly mäihies- Meal gun
Bar crake and acelale balfer
Fiokmehy ageals - dert , rad

Monta sequined soso merida. accord fo
He mes va Jordan, wer weigned
and diffea o break huge bumps

Rauved vd oy vice to each

and chamfered do Stanles Steel
tiring tank

Ga solvent u preheated m ocean
do fachlate gelbllihy & oo males.

9. Ge mw naher wor added où
mixed rin with a known
RPM about 48 hm

Au comple: sohhligahon 6 wo maleab,

Au prepared Schuhen Ls Area by Un, fille
o A PAS ic

am, pen vw called daifuehin

4

<a che ia filed so stable container
ita by vectom Ailing granny jing 00d
poires ond labeled

y

sutoble evaluakion ess wor pajomed 19
O ably ond apy

9 Ma Aouad produ

Grandes :

LR aw prepared oglmades 4 smells
partida poodes

Ne pres in whtth “He primary powders
putes am made adhe do om ler

multi quid entdhes Called Gnonutalion :

10. chjechues & geanlahen
EEE pio

-Prodares uniform siged pates

= Enable Rapid dissolution dy tablet:

=a inprovo. dy ability do undege Compro
Preveno problem q dut using Comprention:

Granulakion proces Ya comedo by 2 methods

Y dy OS)
compression grandlehon
ue aponulalion
\Wek_brorulaion
édely used -lechnigue for mandattutas 6%
compeened tables

hep 15 Grinding +

png u added do garder

and grounded
Sep 2° Blendig |,
Suitable exapients atlas duintegation ch)
os added 4 mixed in ahlndar-
Shep 3: Formation mes |
Grandebing hqurda au. added to
fem dump man By, poulerd wahenal

4

11. Tat crass Streened do born

render
hep 5: Dayng 4

Tse grandes ax dred do
remove eses liqjuid
elep 6 * Day Sexeering |,
Granules melo in Se
reduction
gep 3 : Lebneation |
jubrcaing agents CGtdant Arktadhesing

agents) as add ond med

Haoughly

Sep 2” Comprenion -
qu ~vexullent grande at tompsesed

ly He competion mchne, ® rn
Aabler

Dry Granulotion 3
As: Grinding

Drag vs added do Grandahe 4 qunted
Sep 2: Blending Ming |
Ga suilable Cdilunbs/ grupierls) orc added
Gnd mixed In blender

12. so» Compachion Y

Atar miring > la poda o hadged

Crk |

Qu sg au broken don by

slo do fem

seen IN J

Ta quals 1.

if

mgh a desned m sh
SK E Being or ong |

Lubicahng agers au added and
\

mixed Among

y
mu resol. guardes au

AH Conpussion

compared. by conprenion machine
Avantages
o police info role
= Gronudes ase more Yfeucble Compared to pacha
More stable and again humdthy and atmospheté

= Seqregakton 8 vu combihank 4 ta paoder emba

Could de asided by genio.

T advantages :
= Mask 4 bille Auen may be problem oth 35
Ape 4 prepaiation,

13. - Unslabihky in presence 6 moulu
= Grandes au not à good meltoi 3. adrinieuns

olen dug A, tow dere

ques:

cabled 15 a Phamaceheal dosage Yomo corpses

Be a mit 07 achve Subsfances and excipient,
usually vo poda form au comprevsed into a

sold docage fpr

fed ankages?

ot vu loner Sf all axel ie form

~ zany do sallow:

= sufeined Release 4 coebicamunt :

Loos ana bla tele con de make) by tng
dechriqpet

= tree chemical , medical ond merobral
Gaby over all dosage Fern

Duadvorfages:

—Dnpficall in swallow por childsen aná wnconsttous
Pakient

"Drugs vith poor wethng y slow dusolution popedies.
os diia do Yormulahe

7 Drago ab are Gensthve do da may repaire
Etaptaldhon or coating

14. Fable Preparcdion? 3 melods *
ee ee

1) Dry grndabion: y os medlioned in ondes.
D] wel granulation .

3) Dreh Comprewilon *

Lheps involved
os | Excipien’s
wes E
+ Daicte

Mixto 04 Cblendex]

Sluggins - emp 03
y
Sememng Istenng
y
Mixing — [baten]
3

Compression .

[Scones with Canscome

15. Capra Los am. a Ghd clsage forms. in which
“mél Fire Linul-_cubétoncés “au enclosed ina
Small 5 plain ltd Lot) —

es quelo apres

ee ot globin cpt» |

e HOC is

Hal au also known os dry led
HG contains two port bo „as Body y and ap. ap
As duug substance — 1s placed in fee EN mi op

2 sd” oe ib, Hence —endlosing He

Mena diaiog 4 Hat : sleps inched am
+) Dipping 5) skepping, :
2 an Pre e 2

Dying, 8) Polishing =

“DDippng : Parr Saintes steel Pins au dipped ich _

gph sodio ~b siemuboneouly me :

Copa and bodies = sha Bee

2 e dpping.— Sof Solukon a maintained ab à
NOS tempesahust— 65 about Reina heaked
— sad “Apps quo —

¡Sconned with ComScanner

16. BEER Pee us EN

: apio as volaked do dubrhke a

——golio- ones Ha pica unitosnly ond to
— Coma formalen 6 heads ab Yu.

Capsule ends :

= 1 A E
ha gelbo a due by a Beak of, cool
cto ema bond sh _

= ale ee
—Ma pins am moved through a seres 6
— oie dying alas ho vemore woher

3 stepping: _4 as ge el
D TT VA series by bre jaw ship Gp
and body pofiond 5 das pie Jom Hu pin: _

09 0d jam A En
à: u Skipped. portions ae 7
ee a —
by k kniveAs en se 2 on

Fi rex mins o tac QE Teg Hee
Cap und a body ax joined and
ejeded kom. machine —

higo don ty mind =
Ron polubing + Reda coke. pon .wed clo dunt
= = and polish - = a

5

¡Sconned with ComSconnel

17. OB se

wings Copsules au med vith do,
FO Broking! Capuulos an fed under soft sotading rush
DSGC SC au one Pete, Sealed, Soft glokin shells,
Gonlaining a, liquid, a Supension GA. a. Seminchd..
Ta qd i prepared in 300=libre stainless steel veyal
4
Gdohin poda u mived with My 0 and gly terio
Healing [-stenngs
Ma molten gelatin mars! ia Jomed
Dw decanted tote. 200-by. mobile vend)
swing
Bln_cclous and favews cn be added

7 Manıhachuing pres om 6) hos ke

May au :
9 Flake process
2) Rotary die potes.

18. = Pacing the per halk a plasticged qbo
E an Me cookie Somalis ie Gol
Application

Sy accion, cho. dancso ta cheek into.
AR die pockaks :

Filing A pods svt Kquor (ed paste

Fly AE oer ha ia ta
rau EN da td en

_Gnsalina_ Ma Sandwich und ange pra 2
thas ex apres oor font | and cado

Ga his powers Mu die cie an soadhined
tado. Ha odon Surface Sy Be duo rollers _

Tu die podets_ on Me left dr olle forma he
men one cu Ah
em Hart side rcolle form ight.
sos it Side lopsule =: ai

notes

19. 07 wer

F 17] JUNE = a
Two plasficigd_gehalin nbbon au
Continuoly ee qe
co sd pde li
ste cello oh Ha rola die ra

Asta deal, role fee tonvogence
à PEA die, pi seals lena

colores and _
ae achewe

ar ee
> ss ip aorta don
2) Peripheral Passerteral_Nubestion,

4) Central Posenteral Nudrtion (CPN

Av offen collid ar WN ‚dchunedı nto _cenbal_ ven
=D indader_lipids . tamos , monol 1-eminoacids PA
dextrose (720) and “hace lun

2) Pa Posplsa) Paulus), Nubition:
= By à died, into a smaller Lo) 1a) veia
add lol limites ok console 2. An
Bene admin

20. sae = 08

JUNE [17]

Pe TPN iothde :_Cbohydıaker
lips A)
= ee

is Ha min sonen By ena
ee is a A soute > bol ne

“wed. cs)

See =
du the puma soute Sj essential aly acids

inoleic)0—TPN
Linoleic__acià is wehul as as preuuson Shy -Prrstgfactinn

onda la Syrttussa 0% cit tally neds wind)
Eine a

© Blecholgtes: Na 100- TEA men CA aes

ty pie set ed

i. [et = 100~ 200, me en vs =
amis: Pr dar emo of Jet
Soluble Er = ae shad

ye oles æ TPN. orltion ue

21. (a7) une

= Thee Vitamia ate. vespomible Avy. melobehsm 8

* Cosbohydaates, Proteins, fats -

> Fak Soluble Vik-& DEL ko
aba. soluble vit - 81,82. ,B3.B5 1 Be, Ba, Bote

© Adminwbalton 6h TPN Carr “ation side

— De TPN & ademavtered’ “ouh a needle | Calder
Met placed in a ge vin à Shak ques Aue do
“Hu heost. called N Central Venous —catfeter" _
= Since ex ceatral_venovs_cofteter__need_tp Termin in
place lo. prevent qui complicalicra + TPN mund be
adminutaed 10 a clean and Seule eovimmmnto —__
= fer 1mtante-, extenal hubimg should be charged
_cuey ay. and dressing Should be kapt- steile taille
replacement every 2days

E or t0to_ Ara deg, Pie

“do 7 dies to a week: Most TPN patients _adnsniuter
Aa TN _ioqusion ona pump duung La night Ye |
£19 =1iphys, to they au fut adminiakesing Pumps
dung. day Zn | |

Lobelling ox. Solutions : RE 3 =
ICH un de eg
8 contain Name, e NA
Teatubiens pcan: ge dale Sod colon dada
1018 be Het in. weluguialod ark | da dim Sue
= TPN goluhons should not -be-mxed with oftas IV —
—Solubion unless As disused with te phamaca +
dune compahbihhg + =

[Scanned wih Comscannerl

22. SATURDAY | 0

807]

Le ability Fo _absorb. mubuienh via Gt

pa popineoplashe Hua y vado draps and,

» =Embical_ cor sihuabiows,, eating disctder.and
_hyperemens de aa is
"= Organ Asibaes — lives , wena) ¡respirador
* Disconlinuodion_ 6% TPN: ___ —-
vs Codtinuation y TPN. should Fake place wher He
patient can_<ehishy. "351 alba Calorie’ and parte
"need hal intakı or 9 enteral feedings
—= fo_dacoctinut TPN, ate ehesten ele thou de
halved poe Abre, hoke again the next brand an _
— discontinued si E a6 en,
hu topering...monn-e._preventsryebound hypoglycemia -
ham hyper ta salinemia A an en