MCQs Monkeypox presentation and management Dr Govinda

Q 1. Monkeypox is caused by the monkeypox virus, which is related to the smallpox virus and causes a similar, but usually milder, illness. The virus is thought to spread via which of the following animals?
A. Birds
 B. Mosquitoes
 C. Pet monkeys
 D. Small rodents

1. Q 1. Monkeypox is caused by the monkeypox virus, which is related to the
smallpox virus and causes a similar, but usually milder, illness. The virus
is thought to spread via which of the following animals?
A. Birds
 B. Mosquitoes
 C. Pet monkeys
 D. Small rodents

2. Answer: D: Small rodents.
Monkeypox is thought to be spread by small rodents and squirrels in the rain forests
of Africa. Choices A and B: Monkeypox is not spread by birds or mosquitoes. Choice
C: Despite its name, monkeypox does not live in and is not spread by nonhuman
primates

3. Q 2. Monkeypox causes a rash that turns into blisters. Which of the
following is not a symptom of monkeypox?
A. Cough
 B. Fever
 C. Headache
 D. Swollen lymph nodes

4. Answer: A: Cough.
Monkeypox is not a respiratory virus and does not cause cough, although some
people with monkeypox develop bacterial infections in the skin and lungs.
Choices B, C, and D are symptoms of monkeypox

5. Q 3. Which atypical symptom is associated with the current monkeypox
outbreak as opposed to previous outbreaks?
A.Anogenital lesions
B.Painful lesions
C.More than 20 lesions in total
D.High fever before rash appearance

6. The 2022 outbreak has produced atypical symptoms when compared with previous
monkeypox outbreaks. These symptoms include:
•Lesions mostly confined to the genital and perianal areas, presenting with anal pain
and bleeding
•Scant or even single lesions, or even the complete absence of skin lesions
•Lack of prodromal symptoms such as fever, myalgias, fatigue, and headache before the
appearance of a rash

7. Q 4. According to the US Food and Drug Administration (FDA), to avoid
false results, clinicians should use which of these as samples for testing?
A.Lesion swabs, taken directly from a growth or rash
B.Saliva
C.Serum
D.Rectal swabs, even in the absence of lesions

8. According to the FDA, to avoid false results, clinicians should use
lesion swabs taken directly from rashes or growths to test for
monkeypox. Testing blood, saliva, and other samples that are not
directly from a lesion can lead to false results

9. Q 5. Which of these medications currently has a compassionate-use exception
by the FDA for monkeypox?
A.Acyclovir
B.Foscarnet
C.Tecovirimat
D.Baloxavir marboxil

10. C. Tecovirimat
Approved for treating smallpox 
disease, tecovirimat also has an off-label
investigational use of treatment (ie, compassionate use) for monkeypox from
the FDA.
 Other monkeypox medications include vaccines and a limited
stockpile of other antivirals such as cidofovir

11. Q 6. Which of these statements regarding the JYNNEOS smallpox/monkeypox
vaccine is most accurate, according to the CDC?
A.Only prophylactic use of JYNNEOS is efficacious
B.JYNNEOS is recommended within 4 days of exposure for healthcare providers
without smallpox vaccination in the previous 3 years
C.Only individuals who have never previously received smallpox vaccination should
receive JYNNEOS after exposure
D.All clinicians and laboratory workers should receive preexposure prophylaxis,
regardless of previous smallpox vaccination

12. The CDC's Advisory Committee on Immunization Practices (ACIP)
updated clinical guidance for monkeypox vaccination
 in June 2022.
The
 ACIP recommends that if a clinician has not received smallpox
vaccination within the past 3 years and is exposed to monkeypox
virus, they should receive JYNNEOS within 4 days of exposure. If it is
received within 4-14 days of exposure, vaccination may mitigate
symptoms without preventing the disease. In the United States, most
clinicians and laboratory workers who are not diagnosing
orthopoxviruses, including monkeypox, are not advised to receive
orthopoxvirus preexposure prophylaxis. People with occupations that
may experience exposure should receive preexposure prophylaxis in
the form of either JYNNEOS or ACAM2000.
B. JYNNEOS is recommended within 4 days of exposure for
healthcare providers without smallpox vaccination in the
previous 3 years

13. Q 7. Human to human monkeypox virus transmission can occur by which of
the following routes?
Select all the correct answers:
a) Respiratory droplets
        
b) Exposure to skin rashes
     
c) Mosquito bites
d) Overuse of drugs

14. a)Respiratory droplets, and
 
b)Exposure to skin rashes
  
 
 

15. Q 8. What is the typical timeframe for the skin blisters or nodules to
start diminishing during Monkeypox infection?
a) 2- 5 days
b) 2- 3 weeks
     
c) 1 week
d) 3- 5 weeks

16. b) 2-3 weeks

17.  Q 9. All of the following are the primary characteristics of the
monkeypox virus,
 Except?
A.It is a double-stranded DNA virus
B.The infection by the virus is a zoonotic infection
C.Human transmission occurs only through close contact with infected
monkeys
     
D.The smallpox vaccine is effective against the monkeypox virus

18. c) Human transmission occurs only through close
contact with infected monkeys

19. Q 10.
 Monkeypox infection has been declared a public health
emergency in 2022 by the World health organization due to the
worldwide spread of the virus.
According to health agencies in the USA which of the following age
group are at higher risk?
A.Children 5 to 10 years old
B.Males 18 years and above
     
C.Infants
 
D.Pregnant women

20.  b) Males 18 years and above