Mechanisms_of_action_of_steroid_hormones.pptx

Shortly Steroid hormone actions on man

1. Mechanisms of action of steroid hormones Fayez Zaghloul ID: 798

2. Mechanisms of action and effects All of these different pathways can be classified as having either a genomic effect , or a non-genomic effect. Genomic pathways are slow and result in altering transcription levels of certain proteins in the cell. Non-genomic pathways are much faster.

3. Genomic pathways In this pathway, the free hormones first pass through the cell membrane Then the steroid binds to a specific steroid hormone receptor Upon steroid binding : one functional DNA binding unit that can enter the cell nucleus. Once in the nucleus, the steroid-receptor ligand complex binds to specific DNA sequences and induces transcription of its target genes.

4. Mechanism of action

5. Non-genomic pathways Non-genomic pathways include any mechanism that is not a genomic effect, there are various non-genomic pathway mediated by some type of steroid hormone receptor found at the plasma membrane. Ion channels, transporters

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