medicinal chemistry 1 carbamazepine.pptx

Carbamazepine is an anticonvulsant.
It works by decreasing nerve impulses that cause seizures and nerve pain, such as trigeminal neuralgia and diabetic neuropathy.
Carbamazepine is also used to treat bipolar disorder.

1. CARBAMAZEPINE Class – B. Pharm. 3 rd year ( 5 th semester) Roll No. – Reg. No - Subject – Medicinal Chemistry – 1 Session – 2020-2024

2. Content Introduction. Structure of Carbamazepine. Properties of Carbamazepine. Mechanism of action. Synthesis of Carbamazepine. Therapeutic Uses of Carbamazepine. Side effects of Carbamazepine. Storage and Dosage forms. Refference

3. INTRODUCTION 8122330

4. Structure of Carbamazepine THE STRUCTURE CARBAMAZEPINE MOLECULE IS ILLUSTRATED BELOW

5. Properties of Carbamazepine Molecular formula – C15H12N2O Molecular weight – 236.27 g/mol Water solubility – 17.7 mg/L ( 20°C ) Pka – 13.9 Toxicity – Mild ingestion cause vomiting, drowsiness,ataxia, slurred speech. Affected Organisms – Human and aquatic organisms

6. Mechanism of action Carbamazepine binds and blocks neuronal sodium channels / voltage sensitive calcium channels.
This results in blockage or suppression of neuronal depolarization and hypersynchronization.

7. Synthesis of Carbamazepine

8. Therapeutic Uses of Carbamazepine Prevention and control of seizures.
Providing relieve from certain nerve pains.

9. Side effects of Carbamazepine Drowsiness.
Nausea.
Vomiting.
Dry mouth.
Headaches.
Liver problems.
Dark urine.
Mouth sores.

10. Uses of Carbamazepin Storage – it should be stored in well closed airtight container. Dosage forms – Carbamazepine tablets B.P.

11. Refference Textbook of Medicinal Chemistry vol – 1, V. Alagarsamy, 3 rd Edition, CBS Publisher and Distributors, Anticonvulsants, page 321-325.