Medicinal Chemistry Tinidazole drug ppt

Tinidazole drug information

1. WELCOME

2. Name : Akangire Vishal Balaji Class : Third year Bpharm Div : A Roll no : 02

3. Tinidazole Tinidazole  is a drug used against  protozoan  infections. Category : Antiprotozoal Agent Class : Imidazole derivative

4. TINIDAZOLE   1-(2-ethylsulfonylethyl)-2-methyl-5-nitro-imidazole

5. MOA : Tinidazole 1) Nitro group reduced in trichomonas by a ferredoxin transport system 2) Free nitro group reduce antiprotozoal activity 3) Acts on DNA leads to DNA damage 4)Cause cell death.

6. Metabolism : Hepatic mainly via CYP 3A4 Metabolized by oxidation, hydroxylation and conjugation Uses : 1) To treat trichomoniasis 2) To treat giardiasis , amebiasis.

7. Side Effects : Sharp ,unpleasant metallic taste. Upset stomach ,vomiting, nausea, loss of appetite

8. THANK YOU