Metal Complexes and Their Applications in Bioassay, Bio-Imaging and Protein Staining.pdf

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ÖÐͼ·ÖÀàºÅ:O614¡¡ÎÄÏ×±êʶÂë:A¡¡ÎÄÕ±àºÅ:10052281X(2010)0120201209
MetalComplexesandTheirApplicationsinBioassay,
Bio2ImagingandProteinStaining
ZhouMing
3
¡¡FeiHao¡¡LiuYang¡¡LiWanfei
(SuzhouInstituteofNano2TechandNano2Bionics,ChineseAcademyofSciences,Suzhou215125,China)
Abstract¡¡Metalcomplexes,whichpossessuniquephotophysicalandphotochemicalproperties,haveplayed
importantrolesinmanyfieldsoflifesciencesandmedicaldiagnostics.Therapidlyexpandingfamilyofmetalcom2
plexes,withlargeStokes2shifts,multi2colortunabilityandstabilityagainstphotobleaching,representsanattractive
resourcetochemistsandlifescientistsseekingnovelbio2labelingandbio2imagingmethodologies.Inthismini2re2
view,wedescribeseveralwellestablishedbioanalyticalandinvitrodiagnosticsystemsthatutilizerutheniumand
rareearthmetalcomplexesastheluminescentlabelingmolecules,gadoliniumcomplexesascontrastagentsinmag2
neticresonanceimagingandnoveliridiumcomplexesascellstainingorproteinstainingagents.Inaddition,the
constructionwithnano2architectureandcombinationwithnanotechnologyforbiomedicalapplicationofpotentialmet2
alcomplexesarealsobrieflyintroduced.
Keywords¡¡metalcomplexes;bioassays;bio2labeling;proteinstaining;bio2imaging
Contents
1¡¡Introduction
2¡¡Metalcomplexesusedincommercialtechnologies
211¡¡Ru(bpy)
2+
3andotherrutheniumcomplexescon2
tainingNNbidentateligands
212¡¡Luminescentrareearthmetalcomplexes
213¡¡Contrastagentsformagneticresonanceimaging
3¡¡Iridiumcomplexesandtheirpotentialapplications
311¡¡Cellularimaging

2. © 1994-2010 China Academic Journal Electronic Publishing House. All rights reserved. http://www.cnki.net
¡¤202¡¡¡¡¡¤ »¯¡¡ѧ¡¡½ø¡¡չ µÚ22¾í
312¡¡Bio2labeling
313¡¡Proteinassay
4¡¡Metalcomplexnano2architecturesforbioassay
5¡¡Summaryandprospects
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