Metoclopramide Midication

metoclopramide definition and mechanisms

1. Metoclopramide Name: Sayid Omar Ahmed Abdi MBBS17A

2. Metoclopramide Metoclopramide is in a  class  of medications called prokinetic agents. T hat increases the (movements and contractions) of the stomach and upper intestine. It is used to treat certain stomach problems, nausea and vomiting caused by chemotherapy.

3. Metoclopramide And also available it is available 10mg tablet injection My be oral solution

4. Mechanism of Action Dopamine antagonist Antiemetic agent Stimulates upper GI Antiemetic properties tract motility Accelerated gastric empting A ntagonist of central and intestinal transit and peripheral dopamine receptors And increasing resting tone of lower esophageal sphincter

5. Uses Nausea and Vomiting in adult D iabetic gastroparesis GERD( GastroEsophageal Reflex Disease) Prophylaxis of postoperative nausea and vomiting (when nasogastric suction is undesirable) Facilitation of small bowel intubation (Tube doesn't pass pylorus with conventional maneuvers)

6. Usual Dose In adults under 60kg : 15mg/day in 3 divided doses In adults over 60kg : 30mg/day in 3 divided doses In the interval between each dose should be at least 6Hours

7. Contra-indication Patients in whom increase in GI motility could be harmful: GI Hemorrhage Mechanical Obstruction Perforation Pheochromocytoma Epilepsy

8. WARNING DO NOT ADMISTER TO GILDREN < 18 YEARS OLD REDUCE THE THOSE BY HALF IN PATEINT IMOAIRMENT MONITOER USE IN PATEINT >60 YEARS OLD IN PATEINT EPILEPSY OR PARKINSON`S DISEASE

9. Adverse Effects Precautions Drowsiness, taken 30m before meals Confutation Do not combine with levodopa Dizziness (antagonism) Allergic reaction Avoid combination with CNS Neuroleptic Malignant Syndrome depressants Extrapyramidal symptoms seizures (specially in epileptics)

10. Storage Store metoclopramide at room temperature. Keep it between ( 20°C up to 25°C ).