MHC and HLA CLASSES K R.pptx

MHC and HLA K R.pptx

1. MHC AND HLA SYSTEM K R MICRO NOTES 1

2. CONTENT Introduction Definition History Classes of MHC molecule Structure of MHC molecule Function of MHC molecule HLA (human leuckocyte antigen) Classes of HLA Summary Reference K R MICRO NOTES 2

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13. COMPARISON OF CLASS I AND II MHC ANTIGENS K R MICRO NOTES 13

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15. CLASS III MHC MOLECULE Class III MHC molecule include several secreted antigens such as COMPLEMENT SYSTEM [C2, C 4 and B factor], cytokines[TNF,LTA,LTB],and heat shock proteins. K R MICRO NOTES 15

16. CLASS IV MHC MOLECULE Class IV MHC molecules are present on T cells of leukemia( Tla ) as well as on immature thymocytes which lose Tla during differentiation into mature T cells K R MICRO NOTES 16

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19. HLA forms part of the major histocompatibility complex(MHC) Found on the short arm of chromosome 6 MHC antigens are integral to the normal functioning of the immune response Essential role of HLA antigens lies in the control of self recognition and thus defence against micro-organisms and surveillance. HLA- structure and function Class I molecule (HLA-A,B,C) Expressed on all nucleated cells Presents endogenous Ag to T-lymphocyte(CD8+) Class II molecule (HLA-DR-,DQ,DP) expressed on B lymphocyte, activated T lymphocyte, monocyte , macrophage, dendritic cells, etc. Presents exogenous Ag to helper T –lymphocyte(CD4+) K R MICRO NOTES 19

20. CHROMOSOME NUMBER SIX OF MAN SHOWING HLA K R MICRO NOTES 20

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