Microsphere technology Ip-II unit1.pptx

Industrial pharmacy.

1. Microsph e re Prepared By:- Ms. Pranali Krishan Chavan . Final year( sem VII)

2. Microspheres and Microcapsules Solid spherical particles made of polymers, with drug dispersed throughout the matrix. Microcapsules are small particles with a drug core surrounded by a polymer shell. - Pranali Chavan

3. History of Microspheres 1 1930s Bungenberg de Jong and coworkers work on entrapment of substances with coacervates. 2 1960s Microspheres begin to be used in industry. - Pranali Chavan

4. TYPES OF MICROSPHER :- Bioadhesive microspheres Magnetic microspheres Floating microspheres Polymeric microspheres Biodegradable polymeric microspheres Synthetic polymeric microspheres Radioactive Microsphare - Pranali Chavan

5. Advantages of Microspheres 1 Accurate Delivery Facilitates delivery of small quantities of potent drug. 2 Drug Protection Provides protection for unstable drug before and after administration. 3 Controlled Release Enables controlled release of drug, ex: narcotics, antagonists, steroid hormones. 4 Improved Bioavailability Better drug utilization improves bioavailability and reduces adverse effects. - Pranali Chavan

6. Disadvantages of Microspheres Cost Materials and processing costs are higher than standard formulations. Environmental Impact Fate of polymer matrix and its effect on the environment. Reproducibility Reproducibility is less. - Pranali Chavan

7. Ideal Characteristics of Microspheres Drug Incorporation Ability to incorporate high concentrations of drug. Stability Stability of preparation after synthesis with acceptable shelf life. Controlled Release Release of active reagent with good control over time scale. Biocompatibility Biocompatibility with controllable biodegradability. - Pranali Chavan

8. SINGLE EMULSION TECHNIQUE DOUBLE EMULSION TECHNIQUE POLYMERISATION TECHNIQUEA A) Normal Polymerisation Bulk polymerization Suspension polymerization Emulsion Polymerization B) Interfacial Polymerizations 4. COACERVATION PHASE SEPERATION 5. SPRAY DRYING & SPRAY CONGEALING 6. SOLVENT EXTRACTION MICROSPHERES PREPERATION METHODS Pranali Chavan

9. 1 1 1 ) SINGLE EMULSION TECHNIQUE Pranali Chavan

10. 2 DOUBLE EMULSION TECHNIQUE - Pranali Chavan

11. Polymerizations Pranali Chavan

12. POLYMERISATION TECHNIQUE Normal Polymerisation Bulk polymerisation Suspension polymerisation Emulsion polymerisation Pranali Chavan

13. Interfacial Polymerisation Pranali Chavan

14. SPRAY DRYING & SPRAY CONGEALING Pranali Chavan

15. SOLVENT EXTRACTION Pranali Chavan

16. Thank you