Прорив у лікуванні сепсису: Molecular Mouse на передовій діагностичних інновацій

Надія Терент’єва, науковий директор Хоупмедікаллаб

1. hal

Mpopms y nikypaHHl
cencucy: Molecular Mous
Ha nepexoBiä iHHoBayin

KWIMA Ukraine
Wilw.hopemediab coma

MOLECULAR

2. CENCUC CbOTOAHI

Npu6av3Ho 47-50 minbiionis
Bunagxis cencucy Tpannaeroca no
BCbOMy CBITY KOKHOTO AHA.

B 40% Bunaaxis — ye air fo 5 pokis.

Ino6anbHO, ax minimym 1 3 5-Tu
cmepTeú noB’A3aHa 3 cencucom.
11 minbiionis cmepreñ Ha pik

BcecsitHii AeHb 6oporb6n i3 cencucom —
BIA3HayaeTbca LLOpiuHo 13 Bepecua. Bin 6yB
3acHoBaHnu Ana NiABUWeHHA O6I3HAHOCTI npo
cencvc, 3arPO3AUBUË ANA KUTTA CTAH, UNO
BUHNKAE, KonN peakujia OpraHi3my Ha iHbekuito
BUKNUKAE NOLWKOAYKEHHA B/1ACHUX TKAHUH i
opraHis. Metoto Uboro AHA € iIHbopMyBaHHA
HaceneHHA Npo MPMYMHN po3BuTky cencucy,
Moro He6e3neyHi HacniaKu Ta cnoco6u 3axucty
Big HbOTO Ta OcBiTa MEAUM4HUX npauisHukis,
nauientis Ta LIMPOKOÏ FPOMAACLKOCTI PO
CHMNTOMN, puauku Ta NpodinakTuky cencucy;
OCKIAbKM Cencuc e OCHOBHUM DaKTOPOM
netanbHocTi BHacniaok Gineuocti inpexuidHunx
3aXBOPIOBaHb.

www.hopemediab.com.ua

3. CENCUC 3ABTPA

3a ouiHkamu excneptis 40 2050 pory, 10
minbúoHis cmeptei no Bcbomy CBITY 6yAyTb
copuyuHeni CTIMKICTIO AO aHTU6ÏOTUKIB
(AMR), Wo 3po6uTB ji cmepTenbHiwotlo 3a pak

3acTocosytoun HeafeKBaTHy No Ameca Ÿ
aHtubiorukoTepanito puzuk BTPATH nauieHta |
MOABOIDETLCA, MPM NOYATKOBO BUCOKOMY Latin America arica YN Y Oceania

392,000 4,150,000 22,000

(30%) puzuky cmepri nauieHTa. OcHoBHoto
NpnunHoto HeebekTHBHOCTi emnipuyHol

Tepanil € LUBHAKE NOLIMPEeHHA PE3UCTEHTHUX
MikpoopraHi3mis.

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4. BaWXSUBICTD LUBNAKOI
iaeHtndikauyii CENCUCY

* 3meHlieHHA Óe3kOHTponbHoro
BUKOPUCTAHHA AHTUBIOTUKIB

+ LBuaxkuü nouaTok nPpaBunbHoi
uinecnpamoBaHoï Tepanii

+ CkopoueHHa Yacy rocnitanizauii Ta
YHUKHEHHA BHYTPILIHbONIKAPHAHNX
inpekuin

* 3MEHLIEHHA BUTPaT Ha OXOPOHY 3A0POB/A
nauyienta

+ TMokpauleHHa BnauBy Ha NikyBaHHa
OpraHi3my 3 MHOXMHHOIO CTIAKICTIO O

"ixis (MDRO) x x
hal PaHHe BUAB/eHHA, LIBHAKA AlIATHOCTUKA, NpaBU/NbHE MKYBAHHA

5. Etionoria cencucy Ta centu4uHoro WOKy

+ Y 6inbwocTi BUnaAKiB CeNTN4HOTO WOKy, HaúyacTiLe NPAUAHOIO E FPAMNO3UTUBHI Ta
TpamHeratusHi 6akrepiï, Taxi AK cradinoKkoKM, CTPENTOKOKM, KMLUKOBA Nauka Ta
cuHborHiáHa nanumuka. PakTOpamn PU3UKY e ocnabneHHa imyHiTeTy, HaaBHicTb
iHBa3uBHUX MpucTpolB, XPOHIUHI 3aXBOPHOBAaHHA, XipyprivHi BTPY4aHHA, Tpasmn, a
TaKOX BiK (HOBOHapoaxeHI, AITHI NtOAM).

+ Pigwe 36yaHnkamn e rpu6u poay Candida. Cria 3anigo3putn nicnaonepauiMHy
inpekujito AK MPMYMHY centuyHoro WOKy y naujenTis, aki HELIOAABHO nepeHecrn
onepaujto.

+ HecneundiuHa, piakicHa dopma WOKy, BHKAUKaHa TOKCHHaMM craginokokis Ta
CTPENTOKOKIB HA3HBAETLCA CHHAPOMOM TOKCUHHOTO WOKy.

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6. CyuacHui cencuc - npouec gaiarHOCTUKH B nabopatopiax
MALIEHT 3 u |
cEncucom

...
ati 4-ID Ta AST
ge x YAC*18 - 48 H
3- A
ATAPOBIN 4ALULI

KIHLEBUÜ
PE3YJIbTAT

1 — KYSIDTYPA KPOBI

(Mosnrusna kynstypa posi
2a 48 ron AO kinuenoro peaynstary)

hal 2 - OAPBYBAHHA 3A TPAMOM * YAC BUKOHAHHA POBIT = 1 + 2 + 3 +4

7. MIKPOBIOJIOTIYHA AIATHOCTUKA IH®EKLIIM KPOBOTOKY

WO MOKHA EMMIPUYHA CKOPETOBAHA KBA3I- UVIBOBA
3POBUTH 3 TEPANIA UbOBA TEPANIA TEPANIA
NNALLEUKU 3

Bi seni TECT IHÉOPMALIA Yac sukoHaHHA
KONbTYPOIO Dap6ysaHHa 3a Tpamom G+/G-/YEAST Xena
KPOBI?
ID (Maldi-Tof) ID Xsan
| : :
Cy6kynerypa c Koporkoio inkyGauieio:
-1D ( Maldi-Tof) D E cae
a - WenaKnii tect na mapxepu crilikocri AST ree
h -Tpagnuiünnd AST a
y
i a Wey AKHH AST AST 4-8 roux
(cucremu Hosoro nokoniknn)

MONEKYNAPHI METOAM Id + Mapkepu criixocri 1-2 rognun

8. PesynbTaTu MeHwe, Hi resurs <A h

MOLECULAR MOUSE
3a rOAUHY IgeHtudikauia naToreHy
Ta BUABNEHHA
cTiAKOCTI/Pe3UCTEHTHOC
Ti 3a AONOMOrOH
TOTOBUX KapTpnnpken

ceece

9. CUCTEMA u EN
MOLECULAR MOUSE x

MOBYSIbHA
KOHOITYPAUIA,

10. 2

5 pi3Hux kaprpugpreú Ana LIBHAKOTO BUABAEHHA mikpoopraHi3mibB, LO MatoTb BaxKnuBe
KNIHIYHE 3HaueHHA, Ta ixHix reHis CTIAKOCTI 40 aHTNBIOTUKIB B NO3ATHBHUX KY/bTYpax Kpobi.
64 pisHi miweni: 44 mikpoopraHismu Ta 20 reHiB CTIMKOCTI

MM GRAM NEG RES MM GRAM POS STAPH MM GRAM POS NO STAPH MM YEAST BLOOD
Igewradixauin Fpam- Igewmbicauía fpamnerarnonnx _ lgewrubikauin Fpam-noammanm — Igenradixayin pan. genrudinauia onaia
nosmmenux me Staph ra rene Candida

Staph ra remis crivixocri

rois crifixocri

Heraruenux 6axrepiit

11. MyrbtunnekcHuó MIP 8 pexxumi peanbHoro yacy

‘@nioopecyenuin KoXHOrO
apasalnynku BMMiploeTLcA 8
peanbuomy daci

[aca]

Amnaiqixania Pesyabtarm B peasmnomy “aci

OAHoyacHo MOXHA BUABUTU AO 18 mimeHeñ. BKntoueHo MO3UTUBHI Ta HeraTMBHi KOHTPONI

12. ToToBuii AO BUKOPUCTAHHA KAPTPUAXK

ToToBuii AO BUKOPUCTAHHA KAPTPUAK — LE ENCKTPUYHO
axTuBHa mikpocucrema Ha OCHOBI yiny 3 KPEMHIHO, aka KEPYE
peakujieto Ta YITKO KOHTpostoe Ti Temnepatypy

RFID-mirka 36epirae
indopmaujto npo npogyxt Ta
TeCTH, Ta BAKOPACTOBYETECA

nporpamHuM 3a6eaneueHHam
Ana nposegenha ananisis
(Hanpuxnaa; nor, Tepmix

npugathocti, ancrpu6’iotop).

Oneparopy He norpi6na
inpopmauja npo nporokon

operas

13. Kaprpuayxi ana camonepesipku

HaaBHIcTb ABOX KaPTPHAXKIB ANA Camonepesipku FAPAHTYE onTumanbHe
yHkuionyBaHHa CHCTEMN Ta ii HagiAHY pobory

* PesucTUBHUÜ KaPTPUAXK: IMITYE
pesucTuBHi XAPAKTEPUCTUKU KAPTPUAKA
IVD 3a Aonomorow kani6poBaHux
onopis.

* OnTHUHUÜ KAPTPHAK: BHKOPUCTOBYE
orTogion Ana nepesipku ONTHUHOÏ
po6otu, ebekTuBHocTi CBitnonioay Ta
NepemukaHHa KaHaniB.

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14. PE3YJIbTATU

Tone Samen
e mere
en sample cr
a sample Deas
ome mp co
sur areas

sang co
Dire rompre

CMD gp sample Rete
vw soma
we comic
now areas
sue mere

a
0
o
o
D
o
Dom
0
0
0
o
=
D
.

CARIB gp sample cat
Fosbecomol samle2ets

SERENA EDO!

38ir npo pe3yAbTATH 10 Ao HAABHOCTI um BiACYTHOCTI mimeneá HAAAETECA pazom 3 amnaidikauiAHOIO kpuBoro Ta

BIANOBIAHUMN 3HaueHHamu Ct, uo 3a6e3neuye uiTKUÜ Ta TOUHM ananiz

15. Po6ouuÿñ npouec 1
ana Baktepin

Nigrotoska spaska

aalimae menwe 5

xouann

Pe, AEE. »
Pree,

pil à

NosurëHa kynbrypa ALERTER Nioginisosani em

Kposi ana Garrepió ÓN Gaxtepil

3ABAHTAMEHHA B
KAPTPHAK

MIATOTOBKA
3PA3KA

3PA30K ANA
TECTYBAHHA

NOYATKOBM 3PA3OK

Ha6ip ana sunineHHa JHK He noTpi6HuA

16. Po6ouni npouec 2
ana l3onboBaHoi KonoHil

5 mks

Pecycnenaysanna 1-2 konomió

KONOHIA Uettpndyrysanua y Vortex
8 Ima crepunbnoi soan

nporarom 10”

3ABAHTAMEHHA B
KAPTPHAK

MIATOTOBKA
3PA3KA

BPA3OK ANA
TECTYBAHHA

NOYATKOBM 3PA3OK

Ha6ip ana BugnineHHa JHK He notpiGHuü

17. Po6ouni npouec 3
ana Apix axis

Kinuesnii pesyasrar “epes 1 roa

e

Miarotoska 3paska sañmae 20 xaunun

„Lil

NosutnsHa kynbrypa kposi ana Heo6xiguuú HaGip ana Buninenuÿ AHK
apixaxis enginenna HK ApiKaxis

MIATOTOBKA
3PA3KA

:3PA3OK ANA
TECTYBAHHA

3ABAHTAMEHHA B
KAPTPUAK

JOHATKOBHÜ 3PA3OK

18. Nepwa mixHapogHa ny6nikauis

Besnke
HOCATHEHHA

> Antibiotics (Basel). 2024 Jun 1:13(6)517. doi: 10.3390/antibiotics1 3060517.

anmu6iomuku (ines)

Granna
Cucrema Molecular Mouse: Hopuii kopucuuii incrpymenT
AJA PopMyBaHHA aHTHMIKPO6HOI Tepanil Ayın BaKKOXBOPUX
ll erynena) nauichriss cencucom

Carola Maur 18, Alessandra Consonni ©, Elena Briozzo, Chiara Giubbi ©, Elisa Meroni ©, silvia Tonolo ra

Indexed in Francesco Lazaro O

PubMed,
Taxox poarasganca tpaquuilinnii pyrununii meroy. Baranom, 3 rpanna 2023 no
civen 2024 y xpurnuno xmopmx nauienris 3 cencmcom Óymo siópamo Ta
npoananisopano sa aonomorono cucremu Molecular Mouse ra cranapruux meropin
100 nOSHTMBRIX KYABTYD KPOBI Pesyasrars Honoro npanany HOBHIENO
cninnajaan si erannaprunmn MeToAamn Y BUNANKY MOHOMIKPOÓMIX KyaBTyp Kponi,
oatiak Gyam BHaBAeHi xeski posóbxnocri 8 nonimixpoOnnx spaskax. Penn crilikocri AO
anrnmipo6nnx npenaparis Gyan suapreni y 35 spasKax, npavomy rpyrn vana Ta

CTX-M-1/9 6y.n nañivacrime BuABACHAMH mimensmn. Tepaniio 6y10 CKOpHTOBAHO Y

19. Busienenna reHiB cTiAKOGTI a0
R-nakramia y Tpam-Heratnannx
GakTepiú 3 nosHTHBHMX KYNSTYP
kpoi 3a AONOMOTO!O
MonekynapHoro aHanisy Ha ocHoBi

Original Research
03 June 2
10 569/feimb 2025.

Gemelli @

$ frontier | rovers

OuintonanHa kaprpunxeñ ana
Biarkoctukn cencucy Molecular
Mouse: HOBi NOPTATUBHI Ta LUBMAK
TECTH ANA BUABNEHHA
MikpoopraHisMis npu nigospi
incpexuió KPOBOTORy

Original Research
29 Juy 2025
10.3389/feimb 20251579074

P frontiers | m

Cucrema Molecular Mouse: Hopi KopuchnH IHCTpyMeHT
Ana hopMyBanHa auTuMmikpo6Hoi Tepanii JUIA
BaxkKoxBopux (Ill cryneHs) nanienrin 3 cencncom

Carola Mauri "0, Alessandra Consonni "©, Elena Brioz20, Chara Giubbi ©, Elisa Meron! ©, Silvia Tonolo
and Francesco Luzzaro ©

antibiotics Antibiotics 2024, 13,517

Onimopanna Mikpo6ionorianux noKasHUKiB Ta
NOTEHLIANIHOTO KAÏHÏAHOTO BILIMBy HOBHX WIBMAKHX
Monekyaapunx añasisis Ha Alarnocrury inbekuiä

KPOBOTOKY
‘Tanja Grubic Kezele 40, Maja Abram and Marina Bubonfa-Sonje 50

Bl microorganisms Microorganisms 2025, 13, 616

20. Ki

y. Clínica
Icnania Universidad
1. Pantie Buäßnenns SHV- -type ESBL 8 kynbrypi de Navarra

kposi 3 Escherichia coli

2. SHV ra SHV-ESBL £scherichía coli panna
inentndikantist 3a norromoroto Molecular Mouse B
aixapui Germans Trias i Pujol

3. Inentupixania criñkocri Enterococcus faecium no
Vancomycin run A 3a norromororo Molecular
Mouse g stikapHi Icnanii

4. OXA-23 Acinetobacter baumanni 2 sunanxn
parmboi inentudikanii sa noromororo Molecular
Mouse octor Josep True

21. © CUCTEMA
“ges MOLECULAR MOUSE

MOLECULAR MOUSE - ue nepwa 8 ceiri pyuna
naathopma ana MAP 8 peanbHomy uaci

NosHa cucrema cknapaereca 3:
+ Mpunaay Molecular Mouse

+ Mporpamnoro 3aßeaneuenna
+ MK 8 komnnekri a60 Hoyröyka

MOAYNbHA KOHOITYPALIA
3a aonomoroio OAHOTO nporpamnoro saßesneuennn
morta kepysaru ao 6 npunapio

roouer oe
MOLECULAR MOUSE INSTRUMENT. 117019000
MOLECULAR MOUSE SYSTEM, ALL-IN-ONE PC S11701.1007-ALL
MOLECULAR MOUSE SYSTEM, NetebookPC $11701.1007
Mie USB HUB 17014003,
Wireles Keyboard UK Version and Mouse 5116029902

USE Hondhe 20 Barcode Reader sous

Bor Code Reoder 10 sui90220 \ \

PEP, mocx 1 morscuuan woLocy MOLECULAR mouse

22. M-SHAKER Ta
Ha6ip M-SMASHER kit

Cuctema Ana WBNAKOTO Ta ebekKTHBHOTO
euainenia AHK apiapkis Ana nozuTuBHol

kyNbTypu Kposi
> + Llienaxa npoueaypa — nue 20 xBuAnH
+ Manexbknii Ta KOMNakKTHuÁ
+ Mpocte BCTaHOBNEHHA, He noTpi6He
4 cepsicHe o6cnyrosysaHHA
= © ABTOPH30BaHHA ANA BUKOPUCTAHHA 3
20 Kaprpna»kem MM YEAST BLOOD
«
PRODUCT cove
M-SHAKER 12301.100
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