Multifactorial diseases medical genetics.pptx

Medical genetics, and some risks associated.

1. NKAMBULE SETSABILE LOBESUTHU GROUP 81B MEDICAL GENETICS MULTIFACTORIAL DISEASES

2. Disease traits: Some disease traits have a clear pattern of inheritance 2

3. Complex genetic diseases 3

4. Risk Factors for Schizophrenia 4

5. Evidence for a genetic contribution comes from risks to relatives 5

6. Affected Probands Unaffected Probands 13 /30 are affected; Risk = 0.433 8 /30 are affected; Risk = 0.267 Relative Risk (RR) = 0.433 / 0.267 = 1.63 In siblings of affected compared to unaffected probands Slide credit: Dale Nyholt 6

7. 1. Disorders with multifactorial inheritance (polygenic)

8. Family Studies Do family studies clearly discriminate between genetic and environmental factors? Families have shared environmental factors Diet Toxins Parenting methods Education Risk of ascertainment bias Genetics and other specialty clinics may attract families with multiple affected members

9. Lecture Summary