Mycotic infections

1. MYCOTIC INFECTIONS Submitted by NILIMA T.S.

2. NORTH AMERICAN BLASTOMYCOSIS Caused by Blastomyces dermatiditis . CLINICAL FEATURES -Tiny miliary abscess or pustules. - crateriform lesions. -Fever. -weight loss. -productive cough.

3. NORTH AMERICAN BLASTOMYCOSIS

4. NORTH AMERICAN BLASTOMYCOSIS -DOUBLY REFRACTILE CAPSULE

5. ORAL MANIFESTATION Tiny ulcer. Abscess formation. HISTOLOGIC FEATURES Inflamed connective tissue. Giant cells and macrophages. Round organism with doubly refractile capsule. Microabscess .

6. SOUTH AMERICAN BLASTOMYCOSIS Caused by Blastomyces brasiliensis . Fungus varies 10um to60um in diameter and is larger than that of north american blastomycosis .

7. SOUTH AMERICAN B LASTOMYCOSIS

8. HISTOPLASMOSIS Also called Darling’s disease. Caused by Histoplasma capsulatum . CLINICAL FEATURES Low grade fever. Splenomegaly . Hepatomegaly . Lymphadenopathy .

9. HISTOPLASMOSIS

10. ORAL MANIFESTATION Nodular,ulcerative or vegetative lesions. Ulcerated areas covered by nonspecific gray membrane. Common on buccal mucosa,gingiva,tongue,palate or lips.

11. HISTOLOGIC FEATURES Organism appear as tiny intracellular structures measuring a little more than 1um in diameter. TREATMENT: Amphotericin B

12. HISTOPLASMOSIS

13. CANDIDIASIS Caused by Candida albicans . CLASSIFICATION: Primary Candidiasis : Acute forms - Psuedomembranous - Erythematous

14. Chronic forms - Hyperplstic Nodular Plaque-like - Erythematous - Psuedomembranous Candida associated lesions -Denture stomatitis

15. - Angular cheilitis - Mediam rhomboid glossitis Keratinized primary lesions super infected with Candida - Leukoplakia -Lichen planus -Lupus erythematosus SECONDARY ORAL CANDIDIASIS

16. ATROPHIC CANDIDIASIS

17. ERYTHEMATOUS CANDIDIASIS

18. HYPERPLASTIC CANDIDIASIS

19. TREATMENT Nystatin Clotrimazole Amphotericin B Miconazole

20. PHYCOMYCOSIS Also called as Mucormycosis,Zygomycosis . Caused by Mucorales and Entomophthorales . CLINICAL FEATURES 2 main types-Superficial -Visceral Visceral-Pulmonary -Gastrointestinal - Rhinocerebral

21. ZYGOMYCOSIS

22. HISTOLOGIC FEATURES Organisms appear large,nonseptate hyphae with branching at obtuse angles. Round or ovoid sporangia. TREATMENT Control of predisposing factors. Surgical excision Amphotericin B

23. ZYGOMYCOSIS

24. RHINOSPORIDIOSIS Caused by Rhinosporidium seeberi . CLINICAL FEATURES Mucoid discharge. Soft polypoid growth spreading to pharynx and larynx. Lesions are vascular.

25. HISTOLOGIC FEATURES Sporangia containing large number of round or ovoid endospores,each 5-7um in diameter. Focal abscess formation and multinucleated giant cells. TREATMENT Surgical removal.

26. COCCIDIODOMYCOSIS Caused by Coccidiodes immitis . CLINICAL FEATURES 2 forms-Primary nondisseminated and Progressive disseminated.

27. ORAL MANIFESTATION Proliferative granulomatous and ulcerated lesions. Lytic lesions of jaw. HISTOLOGIC FEATURES Foci of coagulation necrosis. Endospores within large spherules. TREATMENT Amphotericin B

28. CRYPTOCOCCOSIS Also called as Tolurosis ,European blastomycosis . Caused by cryptococcus neoformans . CLINICAL FEATURES Multiple brown papules. Occurs in patients with malignant lymphoma.

29. ORAL MANIFESTATIONS Non specific single or multiple ulcers. HISTOLOGIC FEATURES Gram positive, budding,yeast -like cell with thick gelatinous capsule. Measures 5-20um with a clear halo. TREATMENT Amphotericin B

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