Myxedema is a condition marked by thickening and swelling of the skin caused by insufficient production of thyroid hormones by the thyroid gland. The function of thyroid hormones is to regulate your metabolism. Myxedema is associated with other symptoms of underactive thyroid, also called hypothyroidism, including lethargy, weight gain, fatigue, depression, and cold sensitivity, among others. Myxoedema
These symptoms include: fatigue, lethargy, mental impairment, depression, cold intolerance, hoarseness, dry skin, weight gain