Nano sensors with their applications

1. NANOSENSORS WITH APPLICATIONS Prathamesh V. Kolekar Dept. Instrumentation Engg . Vishwakarma Institute of Technology, Pune.

2. OUTLINE INTRODUCTION NANOSENSOR TECHNOLOGY TYPES APPLICATIONS FUTURE CHALLENGES

3. INTRODUCTION WHAT IS NANO SENSOR ? NANO+SENSOR

4. INTRODUCTION Sensors operating on the scale of atoms and molecules Smaller size, lower weight, modest power requirements Data storage systems

5. NANOSENSOR TECHNOLOGY PHYSICAL SENSORS CHEMICAL SENSORS BIOSENSORS Bio receptors Transducers D etectors

6. TYPES CANTILEVER ARRAY SENSORS NANOTUBE SENSORS NANOWIRE SENSORS

7. TYPE CANTILEVER ARRAY SENSOR

8. TYPES WORKING

9. FEATURES PRECISSION CANTILEVERS: 300 nm THICKNESS TOLERANCE PRECISSION RESONANCE FREQUENCY: SPECIAL CANTILEVER MOUNT EASY HANDLING: VERTICAL CHIP SIDEWALLS, OPTIONAL NON STICKING CONTAMINATION FREE STORAGE

10. SPECIFICATIONS SIZE / SHAPE RECTANGULAR SHAPED SILICON BARS DUOSENSIS SENSORS (2 CANTILEVERS PER CHIP ) OCTOSENSIS SENSORS (8 CANTILEVERS PER CHIP)

11. APPLICATIONS FOR DIAGNOSIS OF DIABETES MELLITUS Small amounts of acetone in a patient’s breath can be detected by cantilever array sensor technique which may attribute to early diagnosis of diabetes mellitus . FOR DETECTION OF BACTERIAS,FUNGI,VIRUSES antigens on cell membrane surface results in additional mass loading, ultra-sensitively detected by the device using nanochemical oscillator The detection sensitivity is in the order of a single bacterium corresponding to a mass of ~1 pg

12. APPLICATIONS FOR CANCER DIAGNOSIS When the cancer-associated molecules bind to the cantilevers, changes in surface tension cause the cantilever to bend The mass detection limitation of NEMS cantilevers is improved to the enumeration of a single DNA molecule consisting of ~1600 base pairs and weighing ~1 ag (atto = 10^18 ).

13. TYPE NANOTUBE SENSOR

14. SIZE / SHAPE coated with strands of DNA could detect molecules on the order of one part per million

15. PLATFORM The Nano sensors could sniff molecules out of the air or taste them in a liquid, suggesting applications ranging from domestic security to medical detectors .

16. APPLICATIONS FOR BLOOD GLUCOSE MONITARING ENZYME GLUCOSE OXIDASE IS NON-COVALENTLY ATTACHED BRINGS CATALYSATION OF GLUCOSE YIELDING HYDROGEN-PEROXIDE ENZYME IMMOBILISATION ALLOWS FLOW OF CURRENT

17. TYPE NANO WIRE SENSOR

18. STRUCTURE DNA(DETECTOR) NANOTUBE(TRANSMITTER)

19. APPLICATION DETECTION OF SINGLE VIRUS NANOWIRES CONFIGURED AS A FET DETECTION OF SINGLE VIRUS ON RECEPTORS CHANGES CONDUCTANCE NANOSIZED WIRE REQUIRED FOR HIGH SIGNAL TO NOISE RATIO

20. APPLICATION DETECTION OF BIOMOLECULE

21. SILICON NANOWIRE USED FOR DETECTION OF PROTEIN KINASE VIZ CAUSE OF CHRONIC LEUKEMIA SILICON Nano sensor WITH PEPTIDE NUCLEIC ACID DISTINGUISHES BETWEEN THESE MOLECULES

22. FUTURE CHALLENGES TO IMPROVE SENSITIVITY OF CANTILEVER Nano sensor UNWANTED BIOFOULING (DETECTION OF NON-ADSORBING MOLECULE) USUAL DESIGN PROBLEMS FLOW CONTROL RISK AND ECONOMICS

23. THANK YOU