Nanomicelles.pptx

Surfactant nanomicelles:
Definition
CMC (Critical micelles Concentration)?
Types of nanomicelles
Advantages of surfactants nanomicelles
Preparation methods
Characterization of nanomicelles
Therapeutic applications

1. Surfactant Nano Micelles Represented by | Amira Moustafa

2. Topic Overview Definition CMC (Critical micelles Concentration )? Types of Nano Micelles Advantages of Surfactants Nano Micelles Preparation methods Characterization of Nano Micelles Therapeutic applications

3. Definition ? Micelles are colloidal particles formed from aggregation of amphiphilic molecules (ex: surfactants ) in aqueous solution above CMC ( Critical Micelles Concentration ) Amphiphilic molecule (ex: surfactant) below CMC in water posses hydrophilic head and hydrophobic tail this form called ( monomer ) Above CMC , Amphiphilic molecules aggregate to form core-shell shape called micelles ,and this process called micellization .

4. CMC? CMC defined as the concentration of surfactants above which micelles will form so we could deduce that CMC value is a concentration related value .

5. Types of Nano Micelles

6. Advantages of Surfactants Nano Micelles Biodegradability Biocompatibility (Not cause any toxic or injurious effect and not causing immunological rejection) High surface activity

7. Surfactant micelles Surfactant Nano Micelles could solubilize oils or water-insoluble drugs by incorporating the solubilize into the core of micelles

8. Preparation of Surfactant Nano Micelles Using Ultrasonication Surfactant dissolved in distilled water > CMC ----- the solution sonicates for 10- 20 min ----the resulting micellar solution is filtered . Using Vortex Surfactant dissolved in distilled water > CMC ---- the solution vortexed for 15 min ---the resulting micellar solution should be filtered

9. Characterization of Surfactant Nano Micelles FTIR ( function groups & active sites) Transmission Electron Microscopy (TEM ) (morphology) Malvern Zeta Sizer ( particle size & zeta potential)

10. Therapeutic Applications Both biosurfactant and chemical surfactants used for therapeutic applications like: Anti-microbial applications ( so it used in health care as a disinfectant ) Anti cancer applications ( drug formulation , emulsifiers)