Nanoparticles

NANOPARTICLES (SPFT)

1. NANOPARTICLES Presented By- Chetan Vishwanath Pawar M. Pharmacy Sem – II Guided By- Mrs. S. MUTHA Department of Pharmaceutics PDEA’s S.G.R.S. College of Pharmacy Saswad. 1

2. INTRODUCTION CLASSIFICATION OF NANOPARTICLES ADVANTAGES AND DISADVANTAGEF IDEAL CHARACTERISTICS METHOD OF PREPARATION EVALUATION PARAMETER OF NANOPARTICLES APPLICATION OF NANOPARTICLES : REFERENCES CONTENTS -

3. DEFINATION – Nanoparticles are defined as particulate dispersions or solid particles with a size in the range of 10-1000nm. OR Nanoparticles are sub-nanosized colloidal structures composed of synthetic or semi-synthetic polymers.” INTRODUTION

4. Based On Method Of Preparation: Nanocapsules:- drug is confined to a cavity surrounded by a unique polymer membrane. Nanospheres:- the drug is physically and uniformly dispersed.

5. Nanoparticulate drug-delivery systems-

6. Solid Lipid Nanoparticles Polymeric Nanoparticles Ceramic Nanoparticles Hydrogel Nanoparticles Copolymerized Peptide Nanoparticles Nanocrystals and Nanosuspensions Classification Of Nanoparticles:

7. Solid Lipid Nanoparticles: • New type of colloidal drug carrier system for i.v. • Consists of spherical solid lipid particles in the nm range, dispersed in water or in aqueous surfactant solution. Polymeric nanoparticles (PNPs) - are defined as particulate dispersions or solid particles with size in the range of 10-1000nm. • Biodegradable polymeric nanoparticles Polylactic acid (PLA), polyglycolic acid (PGA), Polylactic - glycolic acid (PLGA)

8.  Ceramic Nanoparticles: These are the nanoparticles made up of inorganic(ceramic) compounds silica, Exist in size less than 50 nm, which helps them in evading deeper parts of the body.  Hydrogel nanoparticles: Polymeric system involving the self-assembly and self aggregation of natural polymer cholesterol dextran and agarose cholesterol groups provide cross linking points.

9.  Copolymerized Peptide Nanoparticles: Drug moiety is covalently bound to the carrier instead of being physically entrapped.  Nanocrystals And Nanosuspensions: Pure drug coated with surfactant, Aggregation of these particles in crystalline form .Drug powder dispersed in aqueous surfactant solution.

10. 1) They are suitable for different routes of administration. 2) Carrying capacity of nanoparticles is high. 3) Shelf-stability of drug increases. 4) Ability to sustain and control drug release patterns. 5) Suitable for combination therapy where two or more drug can be co-delivered. ADVANTAGES -

11. 1) High cost 2)Productivity more difficult 3) Reduced ability to adjust the dose 4) Highly sophisticated technology 5) Requires skills to manufacture DISADVANTAGES -

12. It should be biochemical inert , non toxic . It should be stable both physically and chemically in In vivo & in vitro conditions. Specific Therapeutic amount of drug release must be possessed . The preparation of the delivery system should be easy. IDEAL CHARACTERISTICS -

13. Emulsion-Solvent Evaporation Method: Double Emulsion and Evaporation Method: Salting Out Method: Emulsions- Diffusion Method Solvent Displacement / Precipitation method: METHOD OF PREPARATION -

14. Emulsion-Solvent Evaporation Method:

15. Double Emulsion and Evaporation Method

16. Salting Out Method

17. Emulsions- Diffusion Method

18. Solvent Displacement /Precipitation method:

19. 1. Particle size 2. Density 3. Molecular weight 4. Structure and crystallinity 5. Specific surface area 6. Surface charge & electronic mobility 7. Surface hydrophobicity 8. In vitro release Evaluation parameter of nanoparticles :

20. Targeting drug delivery by encapsulation . Nanoparticles for drug delivery into the brain. Nanoparticle for ophthalmic delivery. Topical formulation. Nanoparticles for oral delivery of peptides & portions . Application of nanoparticles :

21. JAPS Nanoparticle: An overview of preparation and Characterization BY Sovan Lal Pal, Utpal Jana, P. K. Manna, G. P. Mohanta, R. Manavalan Pelagia Research Library Formulation, Characterization and Application on Nanoparticle: A Review Abhishek Garg*, Sharad Visht, Nitin Kumar Tropical Journal of Pharmaceutical Research, June 2006; 5 (1): 561-573 Nanoparticles – A Review VJ Mohanraj* and Y Chen REFERENCES