Neoplasiia-Epithelial tumours

Neoplasiia-Epithelial tumours

1. Neoplasia
Epithelial tumours

2. Benign epithelial tumours;
Present in two ways:


Sheet of epithelial cells covering a surface
(Papilloma)

Solid masses of cells separated in to groups by
stromal tissues (adenomas).

3. •Papillomas;
Wart like or papillary out growths
Pedunculated,
Sessile,
Villous.

4. Three types according to the nature
of the epithelial involvement;
•Squamous cell papilloma.
•Transitional cell papilloma
•Columnar cell papilloma

5. Squamous cell papilloma.
Skin, tongue, larynx, anus

Histology: Acanthosis,
Hyperkerotosis,
Parakeratosis.

7. Transitional cell papilloma
•See in the bladder (resembles sea anemone)
Recurrence is high
Haematuria
•Columnar cell papilloma;
can see places with col ep

9. •Other epithelial lesions(heterogeneous group);
Epithelial naevus (developmental)
Verruca vulgaris (virul)
Solar keratosis (sun burns)
Basal cell papilloma
(seborrhoeic keratosis)

11. Basal cell papilloma
•Soft
•Well demarcated
•Raised
•Darkly stained skin lesion.
Histology:
Horn cysts
Basal cell with ovoid vesicular nucleus
Cytoplasm consist of pigmented granules

12. Adenoma;
•Consist of dense collection of acini lined
with cuboidal or columnar epithelium.
•In endocrine gland adenomas no acini can
be seen, (polygonal or spheroidal cells
arranged in solid groups)
•Deep tissue adenomas spherical mass of
cells with a capsule.

15. Benign connective tissue tumours;
•The neoplastic over growth of the tissue (eg
muscle fibroblasts bones etc) and the individual
cells or groups of the cells separate each other by
intercellular substance secreted by tumour cells
them selves.
•The consistency of the tumour depends on the
quality and quantity of the intercellular
substance.
•Poorly delineated stroma consist of blood vessels
and connective tissues. It merge with the
neoplastic tissues.

16. Fibroma
•Not a common tumour
•Circumscribed collection of fibroblast
•Collagen interlaced (Soft or hard depend on
collagen)
Eg Skin, Stomach, Ovary etc

17. Myxoma:
•It is a well circumscribed, oval translucent and grey
colour, Cut surface; Glistening slimy.
•Scattered stellate cells disposed in connective tissue
mucin in which net work of reticulin fibres.
•Found in jaws, heart, and associated with other
connective tissues
•Origin may be from undifferentiated fibroblasts or
primitive mesenchymal cells

20. Epithelial malignancies
•Epthelial Dysplasia amd squamous cell
carcinomas

27. Basal cell carcinoma
•Seen in the skin of dark people
•Face is the commonest site
•Punched out ulcer
•Locally invasive
•Arise from basal cells
•Histology
Coins or sheets of uniform basophilic cells.
Cells are closely packed and polyhedral in shape
Peripheral cell layer of the coins are columnar/cuboidel
Nuclei are ovoid and basophilic, and palisading