Neuromuscular blocking agents

neuro muscular blocking agents,classification of drugs,clinical uses of drugs ,mechanism of action,side effects

1. Neuromuscular Blocking Drugs P. Srinu Asst.Prof. Pharmacology Dept Vignan institute of pharmaceutical technology Duvvada, Visakhapatnam.

2. Neuromuscular Blocking Drugs Neuromuscular-blocking drugs block neuromuscular transmission at the neuromuscular junction, causing paralysis of the affected skeletal muscles. This is accomplished via their action on the post-synaptic acetylcholine (Nm) receptors.

3. Classification

4. Uses Neuromuscular blocking agents are among the most commonly used drugs during general anesthesia. They compete with acetylcholine and interfere with the transmission of nerve impulses resulting in skeletal muscle relaxation

5. Non depolarizing neuromuscular blockers are competitive acetylcholine (Ach) antagonists that bind directly to nicotinic receptors on the postsynaptic membrane, thus blocking the binding of Ach so the motor endplate cannot depolarize.

6. succinylcholine Suxamethonium chloride, also known as suxamethonium or succinylcholine, is a medication used to cause short-term paralysis as part of general anesthesia. This is done to help with tracheal intubation or electroconvulsive therapy. It is given either by injection into a vein or muscle.

7. Pancuronium (trademarked as Pavulon ) is an aminosteroid muscle relaxant with various medical uses. It is used in euthanasia and is used in some states as the second of three drugs administered during lethal injections in the United States. Pavulon ( pancuronium bromide) Injection is a neuromuscular blocking agent used to provide skeletal muscle relaxation during tracheal intubation and surgery.

8. Tubocurarine is a toxic alkaloid historically known for its use as an arrow poison. In the mid-1900s, it was used in conjunction with an anesthetic to provide skeletal muscle relaxation during surgery or mechanical ventilation.