Nitroglycerine drug. ppt

Nitroglycerine drug is a vasodilator .

1. N i t r o g l y c e r i n e H e e n a Hassan B s c . N u r s i ng 2 n d y ear 1 9 4 1 9 2

2. I n t r o d u c t ion N i t r o glycerin b e l o n g s t o d r u g c l a s s N i t r a t e s . I t i s a V a s o d i l a t o r s , W o r k s b y r e l a x ing b l o o d vessels . s o heart d o e s not n e e d t o w o r k h a r d , a n d t h e r e f ore d o e s n't n e e d m u c h oxygen n e e d . N i t r o g l y c e r i n i s u s e d to t r e a t : A n g i na Pectoris. , Heart f a i lure . a n d M I .

3. M e c h a n i s m of A c t ion I n t e r a c t ion with s u l f h y d r y l ( S H - ) g r o u p s ( n i t r a t e r e c e p tors ) i n s i d e c e l l s o f v a s c u l a r s m o o t h c e l l s . S t i m u l ation o f f o r m a t ion o f e n d o t h e l i a l f a c t o r o f r e l a x a t ion o f v e s s e ls ( E R F ) _ n i t r o g e n o x i d e ( N O ) D e c r e a s i ng o f i o n i z e d C a 2 + contents R e l axation , d i l a t ion o f v e s s e ls , i n c l u d ing c o r o n ary . v e s s els .

4. P h a r m a c o k i n e t i c s Rapidly a b s o r b e d f r o m the o r a l m u c o s a . W e l l a b s o r b e d from the g a s t r o i n t e s t inal tract a n d t h r o u gh the s k i n . E x t e n s i v e F i r s t - p a s s m e t a b o l ism . T h e r a p eutic e f f e ct i s a p p a r e n t w i t h i n 1 t o 3 m i n u t e s o f u s e o f s u b l i n g u a l t a b l ets , s p r a y s o r b u c c a l t a b lets . W i t hin 3 t o 6 m i n u tes o f applying a n o i n t m e n t o r t r a n s d e r m a l p a t c h . W i t hin 1 t o 2 m i n u t es a f t e r I V d o s e s .

5. E f fects R e l a x e s b l o o d v e s s el w a l l s . D i l a t e s c o r o n a r y a r t e r ies . R e d u c e s w o r k l o a d o f h e a rt .

6. U s e s M a n a gement of A n g i na P e c t o r i s . H e a r t F a i lure . M y o c a r d i a l I n f r a c t ion D u r a t ion o f action 2 t o 3 m i nutes .

7. A d m i n istration M a n a g ement of A c u t e A n g i n a N i t r o g l ycerine i s g i ven a s s u b l i n g ual t a b l ets , a s u b l i ngual a e r o s o l s p r a y , o r b u c c a l t a b l e t s . T h e s e d o s a ge f o r m s m a y a l s o b e u s e d b e f ore a n a c t i vity o r s t r e ss w h i ch m i g h t p r o v o ke a n a t t ack . O n e s u b l ingual t a b let ( s t r e ngth 3 t o 6 m g ) i s p l a c e d u n d e r t o n g u e .

8. T r e a t ment o f M . I . U s e d i n t r a venou s l y , a n d t o i n d u c e hypotension. O r . C o n t r o l h y p e r tension d u r i ng s u r g ery . I n i tial d o s e = 5 t o 2 5 m g / m i n , a d j u s t ed a c c . t o r e s p o nse .

9. T r e a tment of H e a rt failure. G i v e n i n t r a venou s l y = i n i tial d o s e 5 t o 2 5 m g / m i n . B u c c al t a b l e ts = i n d o s e s o f 5 m g r e p e a ted u n t i l s y m p toms a r e c o n t r o lled . I n c h r onic h e a r t failure = b u c c al t a b . a r e g i v e n 5 t o 1 m g t h r e e t i mes d a i l y .

10. A d v e r s e effect s D i z z iness T a c h y c a r d i a T h r o b b ing h e a d a che L a r g e d o s e s c a u s e v o m i ting R e s t l e ssness B l u r r ed v i s i on Hypo tension S y n c o p e R a r l e l y c y a n o s is F l u s h ing o f t h e f a c e .