Non compartment model

non compartment model for calculation of pharmacokinetic parameters

1. Non- Compartment Model Dr Vandana Gupta Associate Professor Mittal Institute of Pharmacy Opposite Bhopal Memorial Hospital & Research Centre Bhopal 3/30/2020 1

2. Non-compartment model or analysis, also called as the model independent method . This approach based on the Statistical moments theory . 3/30/2020 2

3. What is Non-compartment model? Non-compartmental method used to calculate pharmacokinetic parameters. It does not assume the number of compartments. It assumes that elimination follows first order. This method is simple and used commonly to calculate pharmacokinetic parameters such as half-life, clearance, and volume of distribution. 3/30/2020 3

4. Why do we need Non-compartment model? If the primary requirement is to determine the degree of exposure following administration of a drug (such as AUC), and the drug's associated pharmacokinetic parameters, such as clearance, elimination half-life, T (max), C (max), etc., then Non-compartmental analysis is generally the preferred methodology to use in that it requires fewer assumptions than model-based approaches. 3/30/2020 4

5. How? As per Statistical moments theory or Non-compartmental analysis: 3/30/2020 5 (1) Where MRT = mean residence time AUMC = area under the first moment curve AUC = area under the zero moment curve Mean residence time (MRT) is the average time that the drug stays in the body (or plasma as measured).

6. Continue……….. -AUMC is obtained from a plot of product of plasma drug concentration (C) and time (t), i.e. C.t vs time (t ) from zero to infinity. Mathematically it is expressed as: AUMC= ∫ ˳͊ C t dt (2) - AUC is obtained from a plot of plasma drug concentration (C) vs time (t) from zero to infinity. Mathematically it is expressed as : AUC = ∫ ˳͊ C dt (3) 3/30/2020 6

7. Continue…… The AUMC & AUC can be calculated from the given respective graphs or plots by the “ trapzoidal rule.” (Trapezoidal method involves dividing curve by a series of vertical lines into a number of trapezoids {flat shape with 4 sides} calculating separately the area of each trapezoid and adding them together). 3/30/2020 7

8. Continue…… 3/30/2020 8 AUC and AUMC Plots

9. Continue………. Advantages of Non-compartment model 3/30/2020 9

10. Continue…… 3/30/2020 10 Disadvantages of Non-compartment model

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