Nurokind Injections (Generic Methylcobalamin Injections)

Nurokind Injections (Generic Methylcobalamin Injections) are a synthetic version of Vitamin B12, is used for the treatment of peripheral neuropathies, pernicious anemia, Gastrointestinal pathology, dysfunction, or surgery, Folic acid deficiency, diabetic peripheral neuropathy, megaloblastic anemia and other medical conditions caused due to vitamin B12 deficiency.
Another medicine used to treat the same indications is Cyanocobalamin injection. Cyanocobalamin is a synthetic form of Vitamin B12. In the body Cyanocobalamin is converted to it active form Methylcobalamin.

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Nurokind Injections (Generic Methylcobalamin Injections)

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Nurokind Injections (Generic Methylcobalamin Injections)
Nurokind Injections (Generic Methylcobalamin Injections) are
a synthetic version of Vitamin B12, is used for the treatment
of peripheral neuropathies, pernicious anemia,
Gastrointestinal pathology, dysfunction, or surgery, Folic
acid deficiency, diabetic peripheral neuropathy,
megaloblastic anemia and other medical conditions caused
due to vitamin B12 deficiency.
Another medicine used to treat the same indications is
Cyanocobalamin injection. Cyanocobalamin is a synthetic
form of Vitamin B12. In the body Cyanocobalamin is
converted to it active form Methylcobalamin.

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Nurokind Injections (Generic Methylcobalamin Injections)
Active Ingredient
The active ingredient present in Nurokind
Injections is Methylcobalamin
(Mecobalamin, MeCbl, or MeB12). Each vial
of Nurokind Vitamin B12 injection contains
500 mcg or 1500 mcg of purified
Methylcobalamine.

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Nurokind Injections (Generic Methylcobalamin Injections)
Chemical Structure
The structure of Methylcobalamin is given below:

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Nurokind Injections (Generic Methylcobalamin Injections)
Nurokind Injections are manufactured by Mankind Pharma
Private Limited, India in the strengths of 500 mcg and 1500
mcg of purified Vitamin B12.
(Website: https://www.mankindpharma.com/ )

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Nurokind Injections (Generic Methylcobalamin Injections)
Methylcobalamin Injections – Brand Names
Methylcobalamin is available under
various drug trade names that include
Nurokind, Nuroday, Zatrocob, Zenobal
Plus, Cobamet, Neucobal, Alnerve,
Elmecob, Matilda, Vitcobin, Renerve,
Berubigen, Betalin 12, Cobavite, Redisol,
Rubivite, Ruvite, Vi-twel, Vibisone.

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Nurokind Injections (Generic Methylcobalamin Injections)
Uses of Nurokind Injections
Nurokind Injections (Methylcobalamin Injections) manufactured by
Mankind Pharma Limited, India is used for the prophylaxis and
treatment of Pernicious (Addisonian) anaemia, Peripheral and diabetic
neuropathies and other macrocytic anaemias associated with vitamin
B12 deficiency.
Treatment of optic neuropathies such as tobacco amblyopia and Leber's
optic atrophy. Treatment with Methylcobalamin injection may help to
treat peripheral neuropathies and may improve your symptoms.
Left untreated, a vitamin B-12 deficiency can lead to anemia, fatigue,
muscle weakness, intestinal problems, nerve damage and mood
disturbances.
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Nurokind Injections (Generic Methylcobalamin Injections)
Nurokind Injections Dosage

The dosage of Nurokind injections (Generic Methylcobalamin
Injections) is given below:
Peripheral neurophathies: The usual dosage for adults is 1
ampoule (500 mcg of Mecobalamin) daily, administered
intramuscularly or intravenously 3 times a week. The dosage may be
adjusted depending on the patient’s age and symptoms.
Megaloblastic anemia: The usual dosage for adults is 1 ampoule
(500 mcg of Mecobalamin) daily, administered intramuscularly or
intravenously 3 times a week. After about 2 months of medication,
the dose should be reduced to a single administration of one
ampoule at 1 to 3 months intervals for maintenance therapy.
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Nurokind Injections (Generic Methylcobalamin Injections)
Contraindications
Nurokind injections are contraindicated in persons with a
hypersensitivity (allergy) to Methylcobalamin (Mecobalamin,
MeCbl, or MeB12), pre-existing hypervitaminosis or any of the
other ingredients of this medicine.
Known sensitivity to Cobalt. Methylcobalamin (co-
methylcobalamin) must not be used for the treatment of
megaloblastic anaemia of pregnancy.
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Nurokind Injections (Generic Methylcobalamin Injections)
Storage Instructions

Methylcobalamin Injections (Nurokind
Injections) have to be stored at controlled
room temperature i.e. from 20°C to 25°C (68°F
to 77°F) with excursions permitted between
15° to 30°C (59° to 86°F).
Keep this as well as all other medicines away
from children and pets.
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Nurokind Injections (Generic Methylcobalamin Injections)
Warnings

Mecobalamin (Nurokind injections) is susceptible to photolysis. It must be
used immediately after the package is opened, and caution should be taken so
as not to expose the ampoules to direct light.
Intramuscular administration: In intramuscular administration, caution must
be exercised by following the instructions mentioned below to avoid adverse
effects on tissues or nerves.
a) Avoid repeated injection at the same site.
b) Do not inject in densely innervated site.
c) If insertion of the injection needle causes intense pain or if blood flows back
into the syringe, withdraw the needle immediately and inject at a different site.
The therapeutic response to vitamin B12 may be impaired by concurrent
infection, uraemia, folic acid or iron deficiency or by drugs with bone marrow
suppressing effects such as chloramphenicol.

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Nurokind Injections (Generic Methylcobalamin Injections)
Warnings

A sensitivity history should be obtained from the patient prior to administration of
vitamin B12. An intradermal test dose is recommended before vitamin B12 is
administered to patients who may be sensitive to cobalamins.
Hypokalaemia and cardiac arrest have been reported when megaloblastic
anaemia is treated intensively.
Serum potassium is to be carefully monitored during the initial phase of
treatment in pernicious anaemia.
Vitamin B12 deficiency that is allowed to progress for longer than 3 months may
produce permanent degenerative lesions of the spinal cord.
Do not use vitamin B12 until diagnosis is fully established, as it may mask
symptoms of subacute degeneration of the spinal cord, or of the true diagnosis of
pernicious anaemia.
Folic acid may potentiate the neurological complications of vitamin B12
deficiency, so should not be administered to patients with pernicious anaemia.

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Nurokind Injections (Generic Methylcobalamin Injections)
Warnings

Doses in excess of 10 micrograms daily may produce a
haematological response in patients with folate deficiency;
indiscriminate administration may mask the true diagnosis of folate
deficiency.
A vegetarian diet which contains no animal products (including milk
products or eggs) does not supply any vitamin B12. Patients
following such a diet, should be advised to take oral vitamin B12
regularly.
Treatment with vitamin B12 may unmask polycythaemia vera,
because vitamin B12 deficiency may suppress the symptoms of this
condition.

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Nurokind Injections (Generic Methylcobalamin Injections)
Side Effects
Side effects of Methylcobalamin Injections (Nurokind) can include the
following:
Dermatologic Effects:Rash ; In the event of such symptoms, treatment should
be discontinued.
Gastrointestinal Effects:Anorexia, nausea/vomiting and diarrhea
Neurologic Effects (Central nervous system): Headache
Anaphylactoid reaction: decrease in blood pressure or dyspnea, may occur.
Patients should be carefully observed. In the event of such symptoms,
treatment should be discontinued immediately and appropriate measures
taken.
Hot sensation
Diaphoresis
Pain/induration at the site of intramuscular injection
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Nurokind Injections (Generic Methylcobalamin Injections)
Side Effects
Tell your doctor as soon as possible if you notice any of the following and they worry
you:Skin irritation and/or pain around the area of injection, Bruising around the area of
injection and any other mild allergies. These are usually mild side effects of using
Nurokind injection, but may be serious.
In case any of the following Methylcobalamin Injection side effects are observed, stop
taking Methylcobalamin and inform your doctor immediately, or go to accident and
emergency at your nearest hospital: severe allergic reaction which may include skin
rash, itching, nausea, sweating, a feeling of warmth, tingling, weakness, tightness of the
throat, pain in the chest, fast heart beat, difficulty breathing, faintness or swelling of the
lips, face, tongue, throat, breathing tubes, hands or feet. Severe pain or inflammation of
the feet, knees, hands, or elbows, sneezing, severe rash, temporary itchiness, blue
discolouration of the skin, bleeding, prolonged stomach pain, severe dizziness or
drowsiness, muscular paralysis, low blood pressure, prolonged nausea or vomiting,
diarrhea, heart failure, vision problems, loss of consciousness. These are serious side
effects. You may need urgent medical attention or hospitalisation.
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Nurokind Injections (Generic Methylcobalamin Injections)
Overdose
Your doctor should be the only person to inject Methylcobalamin, so an
overdose is not likely to occur.
No overdosage has been reported with Methylcobalamin Injections
(Nurokind).
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Nurokind Injections (Generic Methylcobalamin Injections)
Nurokind Injections During Pregnancy
Methylcobalamin Injections (Nurokind Injections) has
been classified by the US FDA as Pregnancy Category C.
This medicine should not be used during pregnancy unless
the benefit outweighs the risk to the fetus. Problems in
humans have not been documented with intake of normal
daily amounts. Vitamin B12 crosses the placental barrier.
There are no studies establishing the safety of this
medicine during pregnancy.
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Nurokind Injections (Generic Methylcobalamin Injections)
For more details on
Nurokind Injections click here
Nurokind Injections (Generic Methylcobalamin Injections) by
Mankind Pharma Private Limited, India.
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