Nutriceutical

For B.Pharm, 6th Semester

1. Nutriceutical NEUTRACEUTICALs

2. DEFINITION The term “Nutraceutical” was coined from “Nutrition” & “Pharmaceutical” in 1989 by Stephen DeFelice MD, Founder and Chairman of the Foundation for Innovation in Medicine (FIM ). Other words used in the context: Dietary supplements, Functional food, Multi-functional Food, etc. NEUTRACEUTICAL is any substance that is a food or a part of food and provides medical or health benefits, including the prevention and treatment of disease.

3. BENEFITS OF NEUTRACEUTICALS May increase the health value of our diet. May help us live longer. May help us to avoid particular medical conditions. May have a psychological benefit from doing something for oneself. May be perceived to be more "natural" than traditional medicine and less likely to produce unpleasant side-effects. May present food for populations with special needs (e.g. nutrient-dense foods for the elderly ).

4. According to American association of nutritional chemists- The product that has been isolated or purified from food and generally sold in medicinal forms not usually associated with food . With passage of dietary supplement, health and education act ( dshea )- Is a product (other than tobacco) that is intended to supplement the diet that bears or contains one or more of the following dietary ingredients: a vitamin, a mineral , an herb or other botanical, an amino acid, a dietary substance for use by man to supplement the diet by increasing the total daily intake, or a concentrate , metabolite , constituent, extract , or combinations of these ingredients. I s intended for ingestion in pill, capsule, tablet, or liquid form. I s not represented for use as a conventional food or as the sole item of a meal or diet.

5. CLASSIFICATION Neutraceuticals can be classified based on: Natural source (Food Source) Pharmacological conditions Chemical constitution

6. 1. Based on FOOD SOURCE Plants– Lycopene , curcumin , ascorbic acid, quercetin,catechins,pectin,elagic acid. Animals– Conjugated lenoleic acid(CLA ), DHA ( docosahexaenoic acid) , EPA( Ecosapentanoic acid ), choline . Microorganism- Bifidobacterium , Lactobacilli, yeast , streptococcus.

7. 2. Base on Pharmacological condition

8. 3. Based on Chemical constituents

9. CATEGORIS OF NEUTRACEUTICALS

10. Broadly can be defined as Nutrients: Substances which have established n utritional functions e.g. Vitamins, Minerals, Amino Acids , Fatty acids, etc. Herbals/ Phytochemicals : Herbs or Botanical products. Dietary Supplements : Probiotics , Prebiotics , Antioxidants , Enzymes, etc.

11. INORGANICMINERAL SUPPLEMENT Calcium: for bone loss & prevention Magnesium : involved in 300 enzymatic rxn & in maintanance of calcium. Manganese : Enzymatic rxn & bone & cartilage formation Boron : for calcium & estrogen level in women Copper : for all tissue (absorb when bound with Aa ) Zinc : Antioxidant system by scavenging free radicals Phosphorus : Maintain bone structure & plasma formation Silicon : Bone formation & calcification. Vitamin : B1, B2, B6, B12, C, D, A, E, K.

12. Source: Chauhan , et al . 2013

13. Indian Market

14. Source: https://www.theinsightpartners.com/reports/nutraceuticals-market Products and Percentages

15. SCOPES OF NUTRACEUTICALS

16. SOME HEALTHIEST FRUITS AND VEGETABLES

17. H erbs/Natural products as health food: FENUGREEK SOURCE : Trigonella foenum-graecum FAMILY: Leguminoseae CHEMICAL CONSTITUENTS : Alkaloids ( gentianine and trigonelline ). flavanoids , coumarins , proteins,amino acids, steroid saponins .

18. FENUGREEK USES : In treatment of anorexia, gastritis. Fenugreek possess laxative, expectorant, demulcent properties. Shows hypoglycemic and hypocholesterolemic properties

19. GINSENG SOURCE : Panax ginseng FAMILY: Araliaceae CHEMICAL CONSTITUENTS: Protopanaxadiol Polysaccharides, Starch , sterols, Polyacetylenes , choline , Vitamins B1,B2,B12, Pantothenic acid, biotin (B6).

20. GINSENG USES : Ginseng helps the body to cope with stress and fatigue In treatment of hypertension and hypoglycemia . Modifies liver function and metabolism.

21. EXAMPLES OF NUTRACEUTICALS CURRENTLY AVAILABLE IN MARKET VITAMIN AND MINERAL SUPPLEMENTS : Vitamin-A (Beta- Carotene) ADDITIONAL SUPPLEMENTS : Cod liver oil, primrose oil, glucosamine , garlic etc. SPORTS PRODUCTS Glucon - D (Heinz ), Glucose D ( Dabur )

22. MARKETED PREPARATIONS

23. REFERENCES De Felice L Stephen. The nutraceutical revolution, its impact on food industry. Trends in Food Sci. and Tech 1995; 6:59-61. Jack DB. Keep taking the tomatoes - the exciting world of nutraceuticals . Mol Med Today 1995; 1(3):118-21. Brower B. Nutraceuticals : poised for a healthy slice of the market. Nat Biotechnology 1998; 16: 728-33. Mannion M. Nutraceutical revolution continues at foundation for innovation in medicine conference.Am J NatMed 1998; 5:30-3 . Pharmacognosy & Phytochemistry , Volume II, Vinod D. Rangari , pg. no. 100- 124 . career piblication . Text book of pharmacognosy and phytochemistry by Biren shah and A.K.Seth , pg.no-471-479 .