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1. Welcome To Research Proposal Presentation Formulation Development & Evaluation of Anti-diabetic Tablet Presented by: Mr. Mandlik Omkar Sopan S.Y M. Pharmacy(Pharmaceutics) Sem-III Roll no. 04 Guided by: Asso. Prof. Ravi Gaware Sir Department of Pharmaceutics Vishal Institute of Pharmaceutical Education & Research, Ale

2. Table of Content Aim & Objective Introduction Need of Research Literature Review Material & Method Research Methodology References

3. Aim: To develop a safe and effective anti-diabetic tablet that helps in managing blood glucose level & improving overall metabolic health in individuals with diabetes. Objective: To improve efficacy. To provide safety. To improve patient compliance. Cost effectiveness. To provide education to patient.

4. Diabetes is a chronic medical condition characterized by high blood sugar levels due to the body's inability to produce or effectively use insulin. There are two main types: Type 1: diabetes, which typically arises in childhood and involves little or no insulin production. Type 2: diabetes, which is more common and often associated with lifestyle factors, leading to insulin resistance. Managing diabetes is crucial to prevent complications such as heart disease, kidney damage, and vision problems. Treatment may include lifestyle changes, medication, and insulin therapy.

5. Symptoms of Type 2 diabetes tend to develop slowly over time. They can include: Increased thirst (polydipsia). Peeing more frequently. Feeling hungrier than usual. Fatigue. Slow healing of cuts or sores. Tingling or numbness in your hands or feet. Blurred vision. Dry skin. Unexplained weight loss.

6. Need of Research: Pediatric Type 2 Diabetes: Understanding the rising incidence in children and adolescents and developing age-appropriate interventions. Patient Education and Self-Management: Enhancing education programs to empower patients in self-monitoring and lifestyle changes. Prevention Strategies: Effective lifestyle interventions, community-based programs, and identifying high-risk populations. Complications: Diabetes can lead to severe complications, including cardiovascular disease, kidney failure, and neuropathy. Research helps develop strategies for prevention and management.

7. Sr.No . Research work Tentative Duration 1 Literature Review 45- 50 days 2 Finalization of Formulation 15- 20 days 3 Selection of API & Excipients 10 days 4 Procurement of API & Excipients 60 days 5 Preformulation Study 30 days 6 Formulation development 30 days 7 Evaluation of Prepared Formulation 30 days 8 In Vitro & In Vivo Study 15-20 days 9 Stability study 30 das 10 Data Compilation & Documentation 30-60 days Plan of Work

8. Material: Ingredient Examples API Anti-diabetic Agent (BCS – III ) Filler Lactose, MCC, Starch, Mannitol Binder PVP, HPMC, Gelatin Disintegrant Starch, Croscarmellose Sodium, Povidone Glidant Talc, Colloidal Silica, Starch Lubricant Stearic acid, Talc, Magnesium Stearate, SLA Coating agent Shellac, sugar coating, Ethyl cellulose, PVA Method: Wet granulation method

9. References: 1. Pizzi , R. A. 2000. Defying diabetes: The discovery of insulin. Mod. Drug Discovery 3: 77-80. 2. Leahy J. L., Cooper. H. E., Deal, D. A. and Weir G. C. 1986. Chronic hyperglycemia is associated with impaired glucose influence on insulin secretion. A study in normal rats using chronic in vivo glucose infusions. J. Clin. Invest. 77:908-915. 3. Bell, G. I. and Polonsky, K. S. 2001. Diabetes mellitus and genetically programmed defects in beta-cell function. Nature 414:788-91. 4. https://my.clevelandclinic.org/health/diseases/21501-type-2-diabetes 5. https://www.sciencedirect.com/journal/international-journal-of-pharmaceutics 6. https://www.accessdata.fda.gov/drugsatfda_docs/label/2020/202293s020lbl.pdf 7. Manju Koli", Lipi Nogai, Maulshree Bhandari, Riya Mishra, Rashmi Pathak, Himanshu Sharma: Formulation And Evaluation Of Berberine Hydrochloride Film Coated Tablet Vol.14 No.2(2023) 8. Mohsin Kazi , Abdulmohsen Alqahtani , Ajaz Ahmad, Omar M. Noman, Mohammed S. Aldughaim , Ali S. Alqahtani . National Library of Medicine. Vol 28(1);2021

10. Thank You