Opv

1. ORAL POLIO VACCINE
OPV









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2. HEADINGS
Type of vaccine.
Composition.
Diluent.
Storage.
Dosage , Schedule & Route of administration.
Efficacy & Protection rate.
Contraindications.
Complications.
VVM

3. Type of vaccine: Live attenuated vaccine

Composition: Trivalent (TOPV) containing all the three strains
POLIO VIRUS (Type: 1,2,3)
Type- 1 > 10
6
CCID
50
Type- 2 > 10
5
CCID
50
Type -3 > 10
5.8
CCID
50
PRESERVATIVE: Neomycin- 15mcg
Kanamycin- 15mcg
STABILIZED with: Mgcl
3

4. STORAGE: at 4
0
c

DOSAGE: 2 drops = 0.1ml

ROUTE OF ADMINISTRATION: oral

SCHEDULE: 0 dose (at birth)
6wks – 10wks – 14wks
Booster dose at- 16-24month

EFFICACY & PROTECTION RATE: 90-95% for life long.

5. CONTRINDICATIONS:
acute infectious disease.
Fever.
Diarrhoea & dysentery.
Leukemia.
Malignancy.
those receiving steroids.

COMPLICATIONS:
Vaccine associated paralytic polio (type:3)

6. CONTRINDICATIONS:
acute infectious disease,
fever,
diarrhoea & dysentery,
leukemia,
malignancy
those receiving steroids.

8. SPOTTING
Identification: Specimen of Trivalent Polio vaccine.
Type: A live attenuated vaccine.
VVM stage – 4
Constituents : attenuated polio virus(sabin)
Type- 1 > 10
6
CCID
50
Type- 2 > 10
5
CCID
50
Type -3 > 10
5.8
CCID
50
PRESERVATIVE: Neomycin- 15mcg
Kanamycin- 15mcg
STABILIZED with: Mgcl
3
Stored at 4
o
c
Dose: 2drops (0.1ml) orally at birth (0 dose)
and 6wks – 10wks – 14wks & booster at 16-24month.
Efficacy & Protection rate: 90-95% for life long
Contraindication: acute illness, diarrhoea, leukemia & those on steroid.
Public health importance: used for active immunization against polio

9. POLIO VACCINE
INACTIVATED (Salk) POLIO VACCINE
IPV
ORAL (Sabin) POLIO VACCINE
OPV
1.

2.

3.

4.


5.

6.




Killed vaccine

Given s.c or i.m

Provides only systemic immunity.

Prevents only paralysis (CNS invasion).


Not useful in controlling epidemics.

Dosing: 4 doses.
Live vaccine

Given orally

Both systemic and local immunity.

Prevents both paralysis and intestinal
re-infection.

Useful in controlling epidemic.

Dosing: 0 – 6 – 10 - 14 wks – 16 to 24month
total 5 doses.