Organic irritant poisoning

toxicology
poisoning
unknown poisons

1. Organic irritant Organic irritant
poisoningpoisoning

2. Toxalbumin / Toxalbumin /
phytotoxinphytotoxin
RicinRicin
CrotinCrotin
Abrin Abrin

3. Ricinus communisRicinus communis
Toxalbumin Toxalbumin
/phytotoxin/phytotoxin
Ricin Ricin
Castor oil is non Castor oil is non
poisonous poisonous
Press cake is Press cake is
poisonouspoisonous
MOA – inhibits MOA – inhibits
RNAPRNAP
Special BP Special BP  Er Er
GIT GIT  Diarrhoea Diarrhoea

4. Croton tigilium Croton tigilium
Crotin Crotin

5. Abrus precatoriusAbrus precatorius
AbrinAbrin
Similar to Similar to
viperin snake viperin snake
venomvenom
HemagglutininHemagglutinin
Lipolytic Lipolytic
enzymesenzymes
MOA – inhibits MOA – inhibits
Protein Protein
synthesissynthesis

6. Ergotism Ergotism
Ergotoxin,ergotaminErgotoxin,ergotamin
e ,ergometrinee ,ergometrine
Stimulate Stimulate
adrenergic adrenergic
receptors –receptors –
periphery and periphery and
centrecentre
Directly stimulate Directly stimulate
muscle fibresmuscle fibres

7. Ergotism – chronic Ergotism – chronic
poisoningpoisoning

8. Capsicum annum Capsicum annum
--capsaicin ,capsicincapsaicin ,capsicin

9. Semicarpus Semicarpus
anacardiumanacardium
Semicarpol Semicarpol
BhilawanolBhilawanol

10. Calotropis Calotropis
UscharinUscharin
CalotoxinCalotoxin
CalctinCalctin
calotropincalotropin

11. Cantharides Cantharides
Spanish fly / Blister beetleSpanish fly / Blister beetle
CantheridinCantheridin