Osteoporosis in detail

complete description in osteoporosis with video of bone formation and bone destruction

1. Molecular Mechanism of Osteoporosis Presented by:- SHOUVIK KUMAR NANDY SHIKHA THAKUR Department of Pharmacology

2. CONTENTS:- Introduction Component of bones Pathophysiology of osteoporosis Molecular signaling of osteoporosis Treatment Bone remodeling Reference Fig:- Osteoporosis bone damage

3. Introduction (1) :- Definition of Osteoporosis:- A medical condition in which the bones brittle and fragile from loss of tissue, typically as a results of hormonal changes or deficiency of calcium or vitamin D. Low bone density. Increase the risk of fracture. Osteoporosis bones Normal bones

4. Composition Of Bone (1) Matrix Cells Organic Inorganic Osteocyte Phosphorus Calcium Non collagenous protein Collagen Osteoclast Osteoblast Fig:- Human Bones

5. Osteocytes:- Are mono nuclear cells in mineralized matrix . Osteoblast:- Responsible for mineralization of bone matrix. Responsible for secretion of type 1 collagen and large number of collagenous bone protein. Osteoclast:- Excusably bone resorbing cell. Appears at site of high bone turn over.

6. Fig:- Pathophysiology of Osteoporosis (3)

7. Pathophysiology of glucocorticoids- induced osteoporosis

8. Fig:- Molecular signaling of osteoporosis

9. Treatment (2) Anti body therapy:- Selerostin inhibitor- Romosozumab RANKL inhibitor- Denosumab DKK- 1 Inhibitor Anti- serotonin therapy Stem cell therapy

10. RANKL inhibitor

11. Bone remodeling (4) :- Bone remodeling is a lifelong process where mature bone tissue is removed from the skeleton and new bone tissue is formed. Sex hormone at puberty contributes in modeling. Also nutrition, life styles and genetic factor. Vit D receptor type 1 collagen, ER, IL-6 IGF-I.

12. Bone remodeling (4)

13. Hormones &growth factor regulating bone formation:-

14. Bone remodeling (4)

15. Reference:- https:// www.youtube.com/watch?v=0dV1Bwe2v6c&t=55ss https ://pmj.bmj.com/content/78/923/526 https:// www.sciencedirect.com/science/article/pii/S1297319X18303476 https:// www.redalyc.org/jatsRepo/3313/331359393004/html/index.html https:// www.youtube.com/watch?v=0dV1Bwe2v6c&t=55s

16. Thank you