pancreatitis medicine school presentation .pptx

pancreatitis medicine school presentation .pptx

1. pancreatitis

2. Acute pancreatitis Ethiology Gallstones Long time using alcohol Hypertriglyceridemia Neoplasia Smoking Drug induced pancreatitis

3. What medications cause pancreatitis? azathioprine 6_mercaptopurine Valproic acid ACE inhibitors mesalazine

4. Pathogenesis: Two main mechanisms of drug induced pancreatitis are: 1. hypersensitivity reactions the most common mechanism 2. accumulation of toxic metabolites that usually occurs a few months after taking the drug

5. Clinical signs and symptoms:

6. Hemorrhagic pancreatitis signs: Gray turner sign Cullen's sign

7. Diagnosis:

8. pancreatitis diagnostic points in ct scan: typical findings. focal or diffuse parenchymal enlargement. liquefactive necrosis of pancreatic parenchyma. infected necrosis. abscess formation. hemorrhage. calcification. retroperitoneal fat necrosis.

9. Metabolic manifestations: Hypocalcemia Hyperglycemia acidosis

10. Pancreatic pseudocyst: A pancreatic pseudocyst is an encapsulated collection of homogenous fluid with little or no necrotic tissue located near the pancreas. It often presents with nonspecific symptoms in patients with a history of chronic pancreatitis and less commonly acute pancreatitis.

11. time frame for pancreatic pseudocysts: 2_4 weeks Clinical manifestations: Abdominal pain Early satiety Nausea and vomit

12. Prognosis:

13. Treatment :

14. Nutritional support Mild pancreatitis Severe pancreatitis

15. Pancreatitis caused by gallstones:

16. Necrotising pancreatitis:

17. Chronic pancreatitis:

18. Clinical manifestations: pain Endocrine and exocrine insufficiency : Steatorrhea Mild exocrine insufficiency causes abdominal bloating and malabsorption of fat-soluble vitamins and also vitamin B12 Severe exocrine insufficiency causes malabsorption and weight loss. Glucose intolerance sometimes occurs in chronic pancreatitis, but overt diabetes usually occurs late in the course of the disease

19. chronic pancreatitis indirect functional tests Indirect functional tests: Fecal fat analysis Fecal elastase Serum trypsin

20. Endoscopic ultrasound (EUS)

21. Chronic pancreatitis treatment