Parenteral of hormonal injection

Parenteral of hormonal injection

1. Parenteral of hormonal injection Md. Jabiur Rahaman Daffodil International University Dept. of Pharmacy

2. Parenteral  drug  administration Parenteral  drug  administration  means, any non-oral of administration , but is generally interpreted as relating to injecting directly into the body, bypassing the skin and mucous membranes. The common  parenteral routes  are intramuscular (IM), subcutaneous (SC) and intravenous (IV).

3. Types of Parenteral route

4. What is hormonal drug? Hormonal drug may include giving hormones to the patient or using medications that decrease the level of hormones in the body. general sense, hormone therapy may be used to treat some forms of cancer. It may also be used for thyroid disorders, and illnesses associated with hormone production or use.

5. Types of hormonal injections H ormonal injections for breast enlargement. H ormonal injection for birth control. H ormonal injections for weight loss. H ormonal injections for contraceptive. H ormonal injections for pregnancy. H ormonal injections for prostate cancer etc.

6. Birth control injection The  birth control shot  is an  injection  of a hormone that prevents pregnancy. Each  shot  prevents pregnancy for three months. The  shot  is also known by the brand name  Depo -Provera, or by the name of the medicine in the  shot , DMPA.

7. Benefits H ighly effective at preventing pregnancy. Injected every 12 weeks. Minimal drug interactions. Decreased risk of iron deficiency anemia. Decreased risk of endometrial cancer.

8. Example Depo-Provera ® Medroxyprogesterone acetate .............400 mg Polyethylene glycol ..................... 20.3 mg Sodium sulfate anhydrous ......................11 mg   and  added as preservative

9. G rowth hormone injections weight loss A few small studies have linked HGH injections with fat loss and muscle gain. But the changes seen were minimal -- just a few pounds -- while the risks and potential side effects are not. And experts warn that HGH is not approved by the Food and Drug Administration (FDA) for weight loss.

10. Hormonal injection for pregnancy An oil-based solution (sometimes called progesterone in oil) Widely used; the oldest, most established method of progesterone delivery Injected into the once a day Require long, thick needle to penetrate layers of skin and fat Difficult to administer by yourself Injections may be painful Skin reactions are common 

11. progesterone Progesterone is a hormone. Hormones are chemicals made by the body.  Progesterone plays a key role during pregnancy. In early pregnancy, it helps your uterus (womb) grow and keeps it from having contractions . In later pregnancy, progesterone helps your  breasts get ready to make  milk. It also helps your lungs work harder to give oxygen growing baby.

12. Injection types There are two kinds of progesterone treatment:  Vaginal progesterone  may help reduce your risk for premature birth. Progesterone shots  may help reduce your risk for premature birth.

13. Hormone therapy and prostate cancer Hormones occur naturally in your body. They control the growth and activity of normal cells. Cancer of the  prostate gland  depends on the male hormone testosterone to grow. So lowering the amount of testosterone in the body can lower the risk of an early prostate cancer coming back after treatment.  

14. There are different types of injections that lower testosterone levels Luteinising hormone (LH) blockers  – include goserelin ( Zoladex ), buserelin ( Suprefact ). Gonadotrophin releasing hormone ( GnRH ) blockers  – degarelix ( Firmagon ), Anti androgens  – include flutamide (also called Drogenil ), bicalutamide .

15. The contraceptive injection If used correctly, the contraceptive injection is  more than 99% effective . It can be useful for women who might forget to take the contraceptive pill every day. The contraceptive injection may provide some protection against cancer of the womb and pelvic inflammatory disease.

16. compositions Contraceptive Injection contains medroxyprogesterone acetate and estradiol cypionate as its active ingredients. Medroxyprogesterone acetate is a white to off-white, odorless crystalline powder that is stable in air and melts between 200°C and 210°C. It is freely soluble in chloroform, soluble in acetone and dioxane , sparingly soluble in alcohol and methanol, slightly soluble in ether, and practically insoluble in water.

17. DOSAE AND ADMINISTRATION FIRST INJECTION Within first 5 days of the onset of a normal menstrual period, or Within 5 days of a complete first trimester abortion, or No earlier than 4 weeks postpartum if not breastfeeding. SECOND AND SUBSEQUENT INJECTIONS Monthly (28 to 30 days) after previous injection, not to exceed 33 days. If the patient has not adhered to the prescribed schedule (greater than 33 days since last injection), pregnancy should be considered and she should not receive another injection until pregnancy is ruled out. Shortening the injection interval could lead to a change in menstrual pattern. Do not use bleeding episodes to guide the injection schedule.

18. Store at 20°-25°C (68°-77°F); excursions permitted to 15-30°C (59-86°F)

19. Possible side effects include: Irregular menstrual periods, or no periods at all. Headaches. Nervousness. Depression. Dizziness. Acne. Changes in appetite. Weight gain.

20.   Side effects from long term treatment Weight gain Memory problems Mood swings and depression Bone thinning (osteoporosis) Risk of earlier heart attack

21. Containers for hormonal injection ideal properties Does not affect its contents No surface changes at temp. & pressure associated with sterilization Should protect from light when the contents are photosensitive Container should be cheap enough to dispose after one use or be easy to clean & reuse

22. Types of containers Ampoules: single-dose glass containers with capacity of 0.5-50ml. Made from neutral or soda glass. Liberate gas particles on opening. Sealed by heat fusion to exclude MO . Used for solutions or powders.

23. storage Many hospital pharmacies are reluctant to store parenteral fluids longer than 24 to 48 h because of concern about possible microbial contamination. We evaluated the safety of prolonged refrigerated storage routinely in a hospital pharmacy and stored at 4°C for up to 15 days.

24. THANK YOU ALL