An article “ Oxidants, Antioxidants, and the Degenerative Diseases of Aging ” explains that all the cells that are dividing in our body experiences up to 10,000 DNA errors, resulting in the development of little cancers or tumors cells. They begin as little as the tip of a ballpoint pen. And, as long as they are unable to get blood supply they cant grow larger, penetrate different organs, spread and cause death. Folkman & Kalluri, explains in their article “ Cancer without Disease ” that: This control of blood supply is done by angiogenesis system. Until the angiogenesis system operates properly, blood vessels grows in the right place at the right time : not too many or not too few but , just the right amount .
our body consists of s ixty thousand miles of blood vessels and their purpose is to carry oxygen and nutrients to the cells that keep s us alive and shield s us from illness. Among all blood vessels, the Capillaries are the tiniest. We have 19 billion of them in our body, and are smaller than a hair. The density and pattern of C apillary d epend s on the function of the organ and amount of blood flow required . As A ngiogenesis is very crucial to maintaining life, it starts in the reproductive system even before conception.
E xample of Angiogenesis w henever we have a deep cut, whether from surgery or trauma, we can notice that changes begin to occur in the affected area within seconds. Thousands of new blood vessels develop in the wound to heal the damaged tissue. This is indeed A ngiogenesis system working throughout th e process . The cut disrupt s normal blood flow and results in hypoxia , or lower oxygen levels . When there is a shortage of oxygen, more blood vessels expand and grows to bring in more oxygen. The purpose of growth factors, which are released by injured cells in response to hypoxia, is to promote Angiogenesis .
The endothelial cells that lines in our veins waits for the growth factor signals. Once they get the signal they spread out, like a rescue squad. They then reaches to the place of injury, and begin to divide and create tubes that develops into new blood vessels . The healing is now started in the injured part. The starting of healing gives Inflammation. When, two types of inflammatory cells, macrophages and neutrophils enters the wound to remove any bacteria and foreign objects, they produce their own angiogenic growth factors, which boost the production of blood vessels.
How does Angiogenesis system activates? A ngiogenesis system continuously determines where and when more vessels are required to maintain the health and functionality of organs . The system always watch es for reducing the size of blood vessels where required. A healthy A ngiogenesis system is intended to achieve the ideal balance and mix of blood vessels, not too few or too many, 24 hours a day. To increase the number of blood vessels, A ngiogenesis inhibitors named as endogenous which naturally exists in the body is used. These inhibitors exist everywhere , including in our muscles, blood, heart, brain, breast milk, and even semen .
The ability of Human Body to control angiogenesis must be in excellent condition. then only it maximise s overall health of an Individual . If this system is not maintaine d than the result could be either: E xcessive angiogenesis : which can feed sick tissues, or, I nsufficient angiogenesis : which can cause tissue loss and death. In order to maintain this system Food plays a vital role more than anything else Foods like soy, green tea, coffee, tomatoes, red wine, beer, and even hard cheese can influence the angiogenesis defense system. More than a hundred different foods, including soy, tomatoes, black raspberries, pomegranate , can help your body's ability to starve cancer and keep th e tumours tiny and harmless.