Passive agglutination

Passive & Reverse Passive Agglutination

1. PASSIVE AGGLUTINATION

2. Passive Agglutination involves indirect interaction of antibody with the soluble antigen by the means of carrier particle. Passive agglutination first, consists of the binding of soluble antigen with the carrier matrix like latex bead, polystyrene etc. In this type, the antigens do not carry epitopes of interest that have to be agglutinated. There is another type, where in place of antigen, known antibodies attach with the carrier matrix refers as  Reverse passive agglutination . And after the attachment of antibody with the carrier molecule, the antigens attach to the Fab sites of the antibody to agglutinate it. Example :  Latex bead agglutination  for both antigen and antibody.

3. Reverse passive agglutination