Pathogenesis of apoptosis complete .pptx

Pathogenesis of apoptosis

1. Pathogenesis of Apoptosis Reference: Chapter.02, Robbins Basic Pathology 10 th edition

2. Apoptosis

3. Apoptosis

4. Mechanism of Apoptosis Apoptosis is regulated by biochemical pathways that control the balance of death- and survival-inducing signals and ultimately the activation of enzymes called caspases . Two distinct pathways converge on caspase activation: T he mitochondrial pathway (Intrinsic) T he death receptor pathway (Extrinsic)

5. Autophagy Autophagy (“self-eating”) refers to lysosomal digestion of the cell’s own components. It is a survival mechanism in times of nutrient deprivation, so that the starved cell can live by eating its own contents and recycling these contents to provide nutrients and energy

6. Other Mechanisms Necroptosis Pyroptosis