Feature
Incidence
Location
Smoking ass.
Paraneoplastic
Syndromes
Fathogenesis
H&E
IHC
SCC
M>F
Central
Smoking ass.
Hypercalcemia
P53
Keratin pearls,
desmosomes
CK, P63, P40
Adenoca
F»M
Perigheral
Non smokers
Migratory
Thrombophlebitis
Glands lined by
pleomorphic cells
Small cell ca
TTF 1, NAPSIN A
M>F
Central
Strongest ass.with
smoking
Kras, EGFR. ALK)V-mye
Small cells, salt and
pepper chromatin,
nuclear moulding.
Azzopardi effect
VNSE, chromo.
Large cell ca
Cushing's syndrome. Gynecomastia
SIADH
synapto, bombesin,
CD 56
M>F
Peripheral
Both
Large, pleomorphic
cels
AseEsosis
*dower OBEs
*AmpHI BOLEmo gE PA
L
Pleuna ague
’most stedee nalia
AsBEsDns
&EADGD ’ bUne8EL SHAED,
Fusifot m toD dite
AsBes mgFELLVaiNO0L
'Bo'ES
STe