Pathology of skin tumors in detail 12.pptx

tumors

1. Non- melanocytic tumour Dr Avinash Thakur Department of Pathology

2. SYALLBUS AETIOLOGY—SQUAMOUS CELL CARCINOMA, MELANOMA AND BASAL CELL CARCINOMA MORPHOLOGY OF MELANOMA BASAL CELL CARCINOMA

3. SKIN TUMOURS Epidermal tumours Adnexal tumours Melanocytic tumours Soft tissue tumors Lymphomas

4. BENIGN Epidermal Tumors Seborrheic Keratosis Acanthosis Nigricans Fibroepithelial Polyp (skin tag)‏ Epidermal (inclusion) Cyst Adnexal tumours : Eccrine, Apocrine Keratoacanthoma

5. SQUAMOUS PAPILLOMA are one of the most common cutaneous lesions also called fibroepithelial polyp, acrochordon , skin tag seen in the neck, trunk, face

6. GROSS MORPHOLOGY soft bag-like tumor has an irregular papillary surface Often attached to surrounding skin by a slender stalk.

7. MICROSCOPY Stratified squamous lining characterized by: Hyperkeratosis Acanthosis Papillomatosis

8. SQUAMOUS CELL CARCINOMA (SCC) Common skin tumor arising on sun-exposed sites in older people Usually discovered when small and resectable . Less than 5% of these tumors metastasize to regional nodes Lesions deeply invasive and involve the subcutis .

9. COMMON SITES Face Pinna of ear Back of hands Mucocutaneous junction Lips ,Anal canal , Glans penis Preexisting inflammatory and degenerative lesions .

10. AETIOLOGY premalignant lesions (actinic keratosis ) exposure to ultraviolet (UV) light Xeroderma pigmentosum (inherited defects in DNA repair) chronic ulcers & draining osteomyelitis old burn scars ( Marjolin’s ulcer) ionizing radiation Industrial carcinogens Immunosuppression

11. GROSS MORPHOLOGY OF SQUAMOUS CELL CARCINOMA Ulcerated growth Fungated or polypoid growth

12. MICROSCOPY OF SQUAMOUS CELL CARCINOMA Invasion Pleomorphism Keratin pearl formation Increased mitosis Necrosis

13. MORPHOLOGY OF SQUAMOUS CELL CARCINOMA

14. BASAL CELL CARCINOMA (RODENT ULCER ) Common skin tumor arising on sun-exposed sites Common in middle aged whites Are slow growing and locally invasive Rarely metastasizes. Most common location:-- Face (90%)

15. AETIOLOGY Exposure to ultraviolet (UV) light Immunosuppression Xeroderma pigmentosum (inherited defects in DNA repair)

16. GROSS MORPHOLOGY OF BCC BCC may manifest as – Erythematous patch papule or nodule with telangiectasis which is often eroded , or ulcerated

17. GROSS MORPHOLOGY OF BASAL CELL CARCINOMA (CONTD) presents as: Telangiectasias (pearly papules with prominent, dilated subepidermal blood vessels

18. GROSS MORPHOLOGY OF BASAL CELL CARCINOMA 2 . Ulcers extensive local invasion of bone or facial sinuses. Rodent ulcers

19. MICROSCOPY OF BASAL CELL CARCINOMA Proliferation of basaloid cells arising from epidermis