Pellets and pelletization process

This is information about pellets and pelletization process
This is made by pralhad shinde

1. Introduction of pellets and palletization process Presented by :- Pralhad D. Shinde (B.pharma 7 th sem ) Roll No. 67 guided by:- Prof. Mr. V. S . Padghan M. Pharm (Pharmaceutics ) Shradha Institute of Pharmacy, K ondala Z amre , W ashim Pin :-444402 2023-24

2. Pellets And Pelletization Process Defination Size Advantages and disadvantage Excipients used in pellets Pelletization techniques R eferences 1Jjj 1. Objectives Slide no. 2 2 3 4 5 13

3. Pellets What are the pellets? . Multiple unit dosage form . Small, free flowing, and spherical Manufactured by agglomeration process . Size – 0.5-1.5 mm 2.

4. Advantages and disadvantage of pellets Advantages Uniformity of dose Good flow property Easy to handle Prevention of dust formation Controlled release Better drug formation 3. Disadvantage Cost Tableting Tough Equipments

5. Commonly used excipients for pellets preparation 4. Table - 1

6. Production of Pellets Drug layering A) Powder layering B) Solution/Suspension layering Extrusion spherionization Cryopelletization Compression Balling Hot melt extrusion 5.

7. (1) Drug layering A) Powder layering It is most widely and easy method which is used in formation of pellets. Powdered drug and excipients or both preformed to form cores with the aid of binding liquid. Both are added simulataneously in a controlled manner . 6. Fig - 1

8. B) Solution/ Suspension layering 7. Fig. - 2

9. 2) Extrusion Spherionization This is the machinery based technique in which drug solution and Binder solution mixed together and by compression they are converted into small pellets. T hey are smooth and small size pellets. T hey are very spherical in nature. 8.

10. 3) Cryopelletization A process in wgich droplets of liquid formulation are converted in solid spherical particles or pellets by using liquid nitrogen as the fixing medium. 9. Fig. - 3

11. 4) Compression In this method, binder solution and drug solution are mixed together and form large lumps. W ith the help of compression technique, the pressure is applied and forms small granules or they are converted into small pellets. 10.

12. 5) Balling In this technique, b inder solution and drug solution binds together with the help of large machine by the equipments and converted into the ball form. 11.

13. 6) Hot Melt extrusion In this technique, the Binder solution is melt at high temperature. I t is same as bolling process. In this method, pellets are obtained in the form of balls. 12.

14. References 1. Liberman , Lachman & J. B . Schwartz, Pharmaceutical Dosage F orms - Tablets, Volume 1-3, P. No. 2 . Liberman & Lachman Pharmaceutical Dosage F orms- Parenteral Medication, V olume- 1 & 2, P. No. https://youtu.be/XAqXaJNL_m0 g oogle.co.in 13.

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