Penis erection physiology

Penis erection physiology

1. PHYSIOLOGY OF ERECTION
Dept of Urology
Govt Royapettah Hospital and Kilpauk Medical College
Chennai

1

2. Moderators:
Professors:
Prof. Dr. G. Sivasankar, M.S., M.Ch.,
Prof. Dr. A. Senthilvel, M.S., M.Ch.,

Asst Professors:
Dr. J. Sivabalan, M.S., M.Ch.,
Dr. R. Bhargavi, M.S., M.Ch.,
Dr. S. Raju, M.S., M.Ch.,
Dr. K. Muthurathinam, M.S., M.Ch.,
Dr. D. Tamilselvan, M.S., M.Ch.,
Dr. K. Senthilkumar, M.S., M.Ch.
Dept of Urology, GRH and KMC, Chennai.
2

3. HISTORICAL ASPECT
•The first description of erectile dysfunction (ED) dates from about 2000 BC and was set
down on Egyptian papyrus. Two types were described: natural (“the man is incapable of
accomplishing the sex act”) and supernatural (evil charms and spells).
•Hippocrates reported many cases of male impotence among the rich inhabitants of
Scythia and ascribed it to excessive horseback riding
•Aristotle - erection is produced by the influx of air.
•Ambroise Paré - accurate account of penile anatomy and the concept of erection.
•Hunter (1787), thought that venous spasm prevented the exit of blood
•Wagner (1981) - increased arterial flow and decreased venous drainage during erection.
3 Dept of Urology, GRH and KMC, Chennai.

4. FUNCTIONAL ANATOMY
•Penis - 2 corpora cavernosa &
corpus spongiosm , encased
with tunica, bucks fascia,
dartos fascia & skin.
•Function – Urinary and
Sexual
4 Dept of Urology, GRH and KMC, Chennai.

5. SKIN OF PENIS
•Penile skin :- Very mobile as its dartos fascia
backing is very loosely attached to Buck fascia.
Highly elastic, without appendages & fat.

•Uncircumcised men:- The prepuce (foreskin) is
the penile skin as it folds over the glans and
attaches below the corona.
5 Dept of Urology, GRH and KMC, Chennai.

6. FASCIA OVER PENIS
DARTOS FASCIA (superficial
fascia)
of colle's fascia in the •Continuation
perineum
•Extends from base to prepuce
•Loosely attached to skin & deeper buck’s
fascia
•Contains superficial arteries ,veins &
nerves
BUCKS FASCIA (deep fascia)
•Tough elastic layer immediately adjacent to
tunica albuginea.
•The corpora cavernosa are surrounded by Buck
fascia dorsally.
•Buck fascia splits  corpus spongiosum
ventrally.
•Deep dorsal vein, Dorsal artery & Dorsal nerve
are contained within bucks fascia.
•Distally attached to glans.
6 Dept of Urology, GRH and KMC, Chennai.

7. TUNICA ALBUGINEA
Bilayered
•Inner layer - Circular, Intra cavernosal pillars
•Outer layer - Longitudinally oriented, Absent between 5- 7° clock
•Emissary veins – between two layers, outer layer compress emissary veins during erection.
With Erection, are tightly stretched, and
in the flaccid state they form an
undulating meshwork
Radiating from this inner layer are
intracavernous pillars that act as struts to augment the septum
and provide essential support to the erectile tissue
The most vulnerable area is located on the ventral groove (between the 5
o’clock and 7 o’clock positions), where the longitudinal outer layer is absent;
most prostheses tend to extrude here
7 Dept of Urology, GRH and KMC, Chennai.

8. CONTENTS OF TUNICA ALBUGINEA
Fibrillar collagen
(mostly type I but also type III)
Collagen has a greater tensile strength
than steel, it is unyielding.
Elastin fibers
•Elastin can be stretched up to 150% of
its length. The elastin content allows
tunical expansion and helps to
determine stretched penile length.
CORPUS SPONGIOSUM
•Lacks an outer layer or intracorporeal struts
•Ensures low pressure structure during
erection
8 Dept of Urology, GRH and KMC, Chennai.

9. •Emissary veins – oblique directed
between two layers  compressed
during erection

•Cavernous Artery & branches of dorsal
artery – more direct route and
surrounded by periarterial soft tissue
sheath
•Protects the arteries from occlusion by tunica
albuginea during erection
9 Dept of Urology, GRH and KMC, Chennai.

10. LIGAMENTS
•Suspensory— Arises from Buck fascia and consists of two lateral bundles and one median bundle, which
circumscribe the dorsal vein of the penis. Main function - to attach the tunica albuginea of the corpora
cavernosa to the pubis. Provides support for the mobile portion of the penis
•Fundiform– Arises from Colles’ fascia and is lateral, superficial, and not adherent to the tunica albuginea of the
corpora cavernosa
•Penile elongation surgery –
suspensory ligament is severed

•Congenital deficieny of
suspensory ligament – unstable
penis / drooping penis
10 Dept of Urology, GRH and KMC, Chennai.

11. CORPORA CAVERNOSA
•Paired cylinders & conglomeration of sinusoids
•Sinusoids – separated by smooth muscle cells,
connective tissues, collagen, arterioles, venules and
terminal nerves
•Crura - Proximal ends, covered by ischiocavernosus
muscle, originate at the undersurface of the
puboischial rami as two separate structures but
merge under the pubic arch (distal to pubic
symphysis) and remain attached up to the glans.
CORPUS SPONGIOSUM
•Single, contains urethra
•Extends – bulb to glans
•Sinusoids are larger
•Tunica is thinner, lacks outer layer &
intracorporeal struts
•Bulb - fixed to perineal membrane , covered by
bulbo spongiosus, narrows to form corpus
spongiosum.
11 Dept of Urology, GRH and KMC, Chennai.

12. PENILE COMPONENTS & THEIR
FUNCTION DURING ERECTION
12 Dept of Urology, GRH and KMC, Chennai.

13. ARTERIAL SUPPLY
Bulbo
Urethral
Cavernosal
Dorsal
INTERNAL
PUDANDA
L
COMMON
PENILE
Perineal branch
13 Dept of Urology, GRH and KMC, Chennai.

14. ARTERIAL SUPPLY
•Bulbo urethral artery – urethra, spongiousm & glans
•Cavernosal artery - cavernous sinus
•Dorsal artery – below the bucks fascia & between dorsal nerves, supplies glans
•Gives circumflex branches which encircle corpora and provide rich blood supply.
14 Dept of Urology, GRH and KMC, Chennai.

15. ARTERIAL SUPPLY
•Dorsal artery - Engorgement of the
glans during erection

•Cavernous artery effects tumescence of
the corpus cavernosum
•Eners it at the hilum of the penis,
where the two crura merge
•Gives off many helicine arteries 
supply the trabecular erectile tissue
and the sinusoids
•Helicine arteries are contracted and
tortuous in the flaccid state
•Dilated and straight during erection


15 Dept of Urology, GRH and KMC, Chennai.

16. ARTERIAL SUPPLY
Three patterns of penile arterial supply:
Type I - airising exclusively from internal pudendal arteries
Type II- arising from both accessory and internal pudendal arteries
Type III - arising exclusively from accessory pudendal arteries

Accessory arteries from
External iliac
Obturator
Vesical
Femoral

•ED - Accessory pudendal artery
•The importance of accessory pudendal artery preservation during radical
prostatectomy was demonstrated by Mulhall and colleagues (2008), who reported
more rapid recovery of sexual function in men who underwent artery-s paring
radical prostatectomy.
16 Dept of Urology, GRH and KMC, Chennai.

17. VENOUS DRAINAGE
17 Dept of Urology, GRH and KMC, Chennai.

18. PERIPHERAL
SINUSOIDS
CORPORAL VENULES
(immediately beneath T.
albuginea)
SUBTUNICAL VENOUS
PLEXUS
EMISSARY VEINS
18 Dept of Urology, GRH and KMC, Chennai.

19. VENOUS DRAINAGE
Subtunical
venules
Emissary veins
Deep dorsal,
circumflex &
periurethral veins
19 Dept of Urology, GRH and KMC, Chennai.

20. VENOUS DRAINAGE
•Glans  Deep dorsal vein
•C. Spongiosum Circumflex, urethral,& bulbar veins
•C. Cavernosa  Mid & distal shafts to Deep dorsal vein
•Proximal to cavernousal & crual veins
•Skin Superficial dorsal vein in turn to saphenous veins
20 Dept of Urology, GRH and KMC, Chennai.

21. NERVE SUPPLY
SOMATIC
Primarily responsible for sensation & contraction of bulbocavernous and
ischicavernous muscle

Sensory receptors – Penile skin, glans, urethra and within corpus cavernosum
FREE NERVE
ENDINGS
Adelta & C fibres
Dorsal nerve of penis
+ Cavernous Nerve
PUDENDAL NERVE
ENTER SPINAL CORD
– S234 ROOTS
21 Dept of Urology, GRH and KMC, Chennai.

22. ONUF’S NUCLEUS – CENTRE
OF SOMATOMOTOR PENILE
INNERVATION
SPINOTHALAMIC &
SPINORETICULUAR PATHWAYS
THALAMUS & SENSORY
CORTEX
SENSORY PERCEPTION – PAIN,
TEMPERATURE, TOUCH
Contraction of the ischiocavernosus
muscles produces the rigid-erection
phase.

Rhythmic contraction and compression
of the bulbocavernosus muscle on the
proximal corpus spongiosum helps
semen expulsion

Impairment of bulbocavernosus and
ischiocavernosus muscles may
impair erection
22 Dept of Urology, GRH and KMC, Chennai.

23. NERVE SUPPLY -
SYMPATHETIC
Sympathetic T11-L2
Sympathetic trunk
Inf. Mesentric &
Sup.Hypogastric
plexus
Hypogastric nerves
Pelvic Plexus
vasoconstriction, contraction of
the seminal vesicles and prostate,
and seminal emission
NERVE SUPPLY :-
PARASYMPATHETIC

S2S3S4
Pelvic splanchnic
nerves
(nervi erigentes)
Pelvic plexus
Preganglionic neurons
synapse to give post
ganglionic cavernous
nerves.
Produces vasodilataion
EJACULATION & DETUMESCENCE ERECTION 23 Dept of Urology, GRH and KMC, Chennai.

24. NEUROPHYSIOLOGY OF PENILE
ERECTION
24 Dept of Urology, GRH and KMC, Chennai.

25. 25 Dept of Urology, GRH and KMC, Chennai.

26. 26 Dept of Urology, GRH and KMC, Chennai.

27. 27 Dept of Urology, GRH and KMC, Chennai.

28. 28 Dept of Urology, GRH and KMC, Chennai.

29. 29 Dept of Urology, GRH and KMC, Chennai.

30. ROLE OF HORMONES
•Androgens
•Act on hypothalamus, important site for modulation of erection.
•Modulate synaptic transmission, synthesis, uptake & release of neurotransmitters
•Deficiency – loss of sexual interest, impaired seminal emission & reduced nocturnal
erection
30 Dept of Urology, GRH and KMC, Chennai.

31. TYPES OF ERECTION
Nocturnal
Occurs Cholinergic neurons in
lateral
Pontine tegmentum is activated
whereas adrenergic neurons in
locus coeruleus & steronergic
neurons in midbrain are silent.
This differential activation
results in nocturnal erection
in REM sleep.
Psychogenic
Fantasy or
audiovisual stimuli.
Impulses from brain
spinal centers
external genitalia
Reflexogenic
Tactile stimuli
pudendal nerves
sacral dorsal horn &
dorsal gray commissure
processed by
interneurons
parasympathetic
cavernous & dorsal
nerves
PRESERVED IN UPPER SPINAL INJURY 31 Dept of Urology, GRH and KMC, Chennai.

32. SMOOTH MUSCLE PHYSIOLOGY IN
ERECTION
32 Dept of Urology, GRH and KMC, Chennai.

33. MECHANISM OF ERECTION
Smooth muscles relax

Artreial fiow increases

Sunusoidial expansion

Compression of sub tunical &
emissary veins

Reduction of flow  Erection
In contrast to many other smooth muscles, corpus cavernosum smooth
muscle is in a contracted state most of the time.
33 Dept of Urology, GRH and KMC, Chennai.

34. MOLECULAR MECHANISM OF SMOOTH
MUSCLE CONTRACTION
1.Cytosolic Free Calcium.
2.Rho Kinase Signaling Pathway
(Calcium Sensitization Pathway)
3.Latch State: A Unique Characteristic of
Smooth Muscle Contraction
4.Pathways Involving Inositol 1,4,5-
Triphosphate, 1,2- Diacylglycerol, and
Protein Kinase C
34 Dept of Urology, GRH and KMC, Chennai.

35. SMOOTH MUSCLE CONTRACTION
35 Dept of Urology, GRH and KMC, Chennai.

36. MOLECULAR MECHANISMS IN SMOOTH MUSCLE RELAXATION
1.Cyclic Guanosine Monophosphate–Signaling Pathway.
1.Nitric Oxide
2.Carbon Monoxide
3.Hydrogen Sulfide
4.Natriuretic Peptides
5.Guanylyl Cyclase
6.Protein Kinase G.

2.Cyclic Adenosine Monophosphate–Signaling Pathway
1.Adenosine
2.Calcitonin Gene–Related Peptide Family. CGRP,
3.Prostaglandins
4.Vasoactive Intestinal Peptide
5.Adenylyl Cyclase
6.Protein Kinase A

3.Cross activation
4.Phosphodiesterase
5.Ion channels
6.Hyperpolarization of smooth muscles
7.Molecular Oxygen
8.Intercellular communications
36 Dept of Urology, GRH and KMC, Chennai.

37. Three isoforms -
nNOS,eNOS, iNOS
nNOS  initiating erection

eNOS  sustaining erection

NITRIC OXIDE
37 Dept of Urology, GRH and KMC, Chennai.

38. SMOOTH MUSCLE
PHYSIOLOGY:-
•Relaxation of the cavernous smooth muscle
is the key to penile erection.

•On entering the smooth muscle cells, NO
stimulates the production of cGMP.

•cGMP activates PKG, which opens the
potassium channels and closes the calcium
channels.

•Low cytosolic calcium favors smooth muscle
relaxation.

•The smooth muscle regains its tone when
cGMP is degraded by PDE.
38 Dept of Urology, GRH and KMC, Chennai.

39. OTHER SIGNALING MOLECULES
•CARBON MONOXIDE – activates guanylate cyclase by direct binding to heme moiety of the enzyme

•HYDROGEN SULFIDE – relaxation of corpus cavernosal smooth muscle

•NATRIURETIC PEPTIDE – In vitro studies – increases cGMP & relaxes cavernous smooth muscle by
binding to NPReceptor




39 Dept of Urology, GRH and KMC, Chennai.

40. PROSTAGLANDINS
•Eicosanoids capable of initiating numerous biological functions through G-Protein coupled receptors.

•Nine known prostaglandin receptor subtypes

•Four of the subtypes (EP1 to EP4) bind PGE2, two (DP1 and DP2) bind PGD2, and the other three subtypes
(FP, IP, and TP) bind PGF2α (FP), PGI2 (IP), and TXA2 (TP)

. On the basis of signaling attributes, the prostaglandin receptors are classified into three types.
“Relaxant” receptors IP, DP1, EP2, and EP4 are coupled to an αs-containing G protein and are capable of
stimulating adenylyl cyclase to increase intracellular cAMP.
“Contractile” receptors EP1, FP, and TP are coupled to an αq-containing Gprotein, which activates phospholipase C
 increase of intracellular calcium
EP3 receptor is also a contractile receptor, but it is coupled to an αi-containing G protein that inhibits adenylyl
cyclase to result in a decrease of cAMP formation.
The erectogenic effects of PGE1 as a pharmaceutic agent have been extensively documented.
Intracavernous injection of PGE1 is one of the safest and most effective treatments for ED;
Transurethral application is an alternative. 40 Dept of Urology, GRH and KMC, Chennai.

41. PHOSPHODIESTERASE
•Termination of cyclic nucleotide signals

•Catalyze the hydrolysis of cAMP and cGMP to AMP and GMP, respectively

•Feedback mechanisms that increase PDE activities and/or expression by the increased cyclic nucleotide level assist cyclic
nucleotide degradation

•11 families (PDE1 to PDE11) that are encoded from 21 distinct genes

•PDE1, PDE2, PDE3, PDE10, and PDE11 hydrolyze cAMP and Cgmp
•PDE4, PDE7, and PDE8 hydrolyze cAMP
•PDE5, PDE6, and PDE9 hydrolyze cGMP

With the exception of PDE6, which is specifically expressed in photoreceptor cells, all PDEs have been identified in the corpus
Cavernosum

PDE5 is the principal PDE for the termination of cavernous cGM P signaling and inhibition of the cGMP-
catalytic activity by PDE5 inhibitors is highly effective in treating ED.

PDE3 also appears to play a role in erection - erectogenic effect of a PDE3-specific inhibitor, milrinone
41 Dept of Urology, GRH and KMC, Chennai.

42. MOLECULAR OXYGEN AS A
MODULATOR
The PO2 level of cavernous blood in the flaccid state is similar to that of venous blood (≈35 mm Hg).

During erection, the large inflow of arterial blood increases PO2 to approximately 90 mm Hg

Molecular oxygen is a substrate, together with L-arginine, for the synthesis of NO by NOS
flaccid state  low oxygen concentration inhibits NO synthesis
erection  higher level of substrate induces NO synthesis

Minimal concentration of oxygen in the cavernous bodies necessary to reach full NOS activity is 50 to 60 mm Hg

Prostaglandin H synthase is also an oxygenase (cyclooxygenase) and uses oxygen as substrate for the synthesis of prostanoids.
Production of PGE1 has been shown to be inhibited in flaccidity and stimulated during erection

Endothelin synthesis is also modulated by oxygen
low oxygen concentration promotes production, whereas a high concen tration inhibits it.
42 Dept of Urology, GRH and KMC, Chennai.

43. INTERCELLULAR COMMUNICATIONS

Presence of gap junctions in the membrane of adjacent muscle cells

Intercellular channels allow exchange of ions such as calcium and second-
messenger molecules

Connexin-43, a membrane-sparing protein of less than 0.25 μm - Identified between
smooth muscle cells of human corpus cavernosum

Cell-to-cell communication through these gap junctions most likely explains the
synchronized erectile response
43 Dept of Urology, GRH and KMC, Chennai.

44. 44 Dept of Urology, GRH and KMC, Chennai.

45. 45 Dept of Urology, GRH and KMC, Chennai.

46. HEMODYNAMICS IN ERECTION
46 Dept of Urology, GRH and KMC, Chennai.

47. PHASES OF ERECTION
•0 – FLACCID PHASE

•1- LATENT PHASE

•2 – TUMESCENCE PHASE

•3 – FULL ERECTION

•4 – RIGID ERECTION

•5 – INITIAL DETUMESCENCE

•6 – SLOW DETUMESCENCE

•7 – FAST DETUMESCENCE
ERECTION = SINUSOIDAL RELAXATION + ARTERIAL DILATATION + VENOUS COMPRESSION
47 Dept of Urology, GRH and KMC, Chennai.

48. PHASES OF ERECTION
Flaccid
Phase:
•Minimal arterial and venous flow
•Blood gases values similar to venous blood
Latent
phase
•Increased flow in int.pudendal artery during both systolic and diastolic phases
•Decreased pressure in int.pudendal artery
•Unchanged intracavernous pressure
•Some elongation of penis
Tumescen
t phase
•Rising intracavernous pressure until full erection achieved.
•Penis shows more expansion and elongation with pulsation.
•With rise in pressure arterial flow decrease and flow occurs only during systolic phases.
Full
erection
phase
Skeletal or
Rigid
erection
Phase:
•Intracavernous pressure rises 80-90% of systolic pressure
•Int pudendal atrery pressure increase but remains slightly below systemic pressure
•Arterial flow remains low but still remains higher than flaccid phase
•Venous channels compressed but still higher than flaccid phase. Blood gas values approaches to that of arterial blood
•Ischiocavernous mus contraction causes rise in pressure well above the systolic pressure lead to rigid erection
•Almost no blood flows through cavernous artery
•As the duration is short so no ischemia or tissue damage
Detume
scent
Phase:
•After ejection or cessation of erotic stimuli, sympathetic tonic discharge resumes.
•Result - tonic contraction of smooth muscle against closed venous system  slow reopening of venous channels
 resumes basal arterial flow  fast pressure decrease with fully restored venous outflow from sinusoids.
•Penis returns to it flaccid length and girth. 48 Dept of Urology, GRH and KMC, Chennai.

49. HEMODYNAMIC CHANGES IN CORPUS
SPONGIOSUM & GLANS DURING
ERECTION
Arterial flow increases, BUT Pressure in the corpus spongiosum and glans is
only one third to one half that in the corpora cavernosa because the
tunicalcovering, which is thin over the corpus spongiosum and virtually absent
over the glans, ensures minimal venous occlusion.

Full-erection phase - partial compression of the deep dorsal and circumflex
veins between Buck fascia and engorged corpora cavernosa  glanular
tumescence

Rigid-erection phase - ischiocavernosus and bulbocavernosus muscles forcefully
compress the spongiosum and penile veins, resulting in further engorgement
and increased pressure in the glans and spongiosum
49 Dept of Urology, GRH and KMC, Chennai.

50. ERECTION
NEURAL INTEGRITY
CAVERNOSAL SMOOTH
MUSCLE
NEUROTRANSMITTERS
&
RECEPTORS
HEMODYNAMIC
CHANGES
50 Dept of Urology, GRH and KMC, Chennai.

51. THANK YOU
51 Dept of Urology, GRH and KMC, Chennai.