Peptic ulcer and drugs used in its treatment

In this ppt you will get to know about what is meant by peptic ulcer, their types, how it causes, ethology, signs and symptoms and most importantly drugs used in the treatment of it and also the mechanism by which drugs are acting.

1. Peptic Ulcer and
drugs used in its treatment
Made by :

1.Tanushri Sakharkar
2.Khushi Kakpure
3.Ashwini Tulavi
4.Harshal Yeole
5.Dr. Vaibhav Upalanchiwar

2. Peptic ulcer is a disease caused due to breaking of inner lining of stomach.
There are two types of peptic ulcer :


●The ulcer caused in duodenum is called as duodenum ulcer.
●It is most common type of ulcer
●The ulcer caused in stomach is called as gastric ulcer.
Peptic ulcer
1.Duodenal ulcer

2. Gastric ulcer

3. Classification Of Drugs
Ulcer Protective
Gastric Acid
Neutralizers
Sodium
Citrate,
Sodium
Bicarb-o
nate
Magnesium
Hydroxide,
Aluminium
Hydroxide,
Calcium
carbonate,
Megaldrate
systemic Non-systemic
Sucralfate,
Colloidal
Bismuth
Subcitrate
[CBS]
Anti H-Pylori
Amoxicillin,
Tinidazole,
Tetracycline
CbS,
Clarithromycin,
Metronidazole
Gastric acid
Secretion inhibitors
Proton pump
inhibitors
H2 receptor
antagonist
Anticholinergic
Prostaglandin
analogue

4. Gastric acid secrtion inhibitors:
1.Proton pump inhibitors : Omeprazole, Lansoprasole, Pantoprazole,
Rabeprazole, Esmoprazole, Dexrabeprazole
2. Anticholinergic : Pirenzepine, Telenzepine, Propantheline,
Oxyphenonium
3.H2 receptor antagonist : Cimetidine, Ranitidine, Famotidine, Roxatidine,
Loxatidine
4. Prostaglandin analogue : Misoprostol, Enprostil, Rioprostil
1.Ulcer causes due to infection with Helicobacter pylori bacteria.
2. Use of drugs like NSAIDS also causes ulcer.
3. Excessive secretion of acid.
4. It can also caused due to viral infection.


Etiology

6. Intake of drugs like Reserpine, Corticosteroids [NSAIDS], alcohol, tea, coffee

Decrease mucus secretion and excess secretion of HCL

Breakdown of inner lining [mucus membrane] of stomach

Due to which acid enters into gastic mucosa

Peptic ulcer
Pathophysiology

7. Mechanism of action :
●Proton pump inhibitors inhibit the proton pump
[H+K+ ATPase] which is stimulated by gastric
parietal cells & secretion of HCL is minimised.
●H2 receptor is responsible for increasing acid
secretion which activates H+K+ATPase by
generating cAMP by action of histamine, H2 blocker
Is given which decrease the acid secretion.
●Gastric mucosa produces PGE2 [ prpstaglandinE2]
Which is responsible for inhibiting acid secretion by
inhibiting cAMP generation.
●Bacteria H pylori is major cause for peptic ulcer by
causing
Hypergastrinemia, so for this anti H pylori drugs are
given.