Phagocytic dysfunction

Phagocyte bactericidal dysfunction refers to a class of medical conditions where phagocytes have a diminished ability to fight bacterial infection. Examples include: Hyperimmunoglobulin E syndrome. Chédiak–Higashi syndrome. Chronic granulomatous disease.

1. PHAGOCYTIC
DYSFUNCTION

2. Genetic in origin
Affect the innate immune system
Neutrophils are impaired and cannot
exit the circulation and travel to the
sites on infection
Cannot produce a normal
inflammatory response against the
pathogens.

3. S/s
Increased incidence of bacterial , fungal
and viral infection
Cutaneous abscess
Chronic eczema
Bronchitis, pneumonia
Chronic otitis media, sinusitis
Neutropenia
Painful mouth ulcers

4. gingivitis
Stomatitis
cellulitis

5. Diagnosis
History
Sign & symptoms
Laboratory analysis of the cytocidal
activity of the cells

6. MANAGEMENT
Early diagnosis of the disease and
treatment
Granulocyte transfusions
Trating with granulocyte macrophage or
granulocyte colony stimulating factor
It will draw nonlymphoid stem cells from
the bone marrow and hasten their
maturation