Pharmaceutical Analysis Nepal Pharmacy License Classes.pdf

#NepalPharmacylicenseexam
#NPC EXAM
#Analysis
#Important

1. PHARMACEUTICAL
ANALYSIS
By Pharmacist: Pawan Dhamala

2. Principal of Analytical Methods
Absorption Methods: Atomic Absorption Method, Ultraviolet & Visible
Method, IR
Emission Methods: Atomic Emission Spectroscopy, Flame
Spectroscopy, Fluorimetry(@ EF)

3. Base on molecular level
•Atomic spectroscopy: Atomic absorption spectroscopy , Flame
photometry
•Molecular spectroscopy: UV, IR, Fluorimetry

4. Acid Base Titrations
•Lewis Acid: Electron Acceptor (LA)
•Lewis base : Electron doner
•Bronsted–Lowry concept Acid: Proton doner
•Bronsted–Lowry concept Base: Proton acceptor
•Arrhenius acid: gives H+ ions in water.
•Arrhenius base: gives OH-ions in water.

5. •Normality:The number of gram equivalentof the solute in 1 Litreof
the solution.
•Molarity:Thenumber of moles of solute per litreof solution.
•Molality:The number of moles of the solute in 1 kg of the solution.

6. @ My Apple is Red& Your
Banana is Yellow.

7. PRIMARY STANDARDS
TITRATION METHOD PrimaryStandard
Acid-Base reactions Na2CO3, Na2B3O7 , C8H5KO4
Complex formation reactionsAgNO3, NaCl
Precipitation reactionsAgNO3, KCl
Redox reactions K2Cr2O7, Na2C2O4, I2

9. •The colourchange for methyl red is …………………… when PH
changes from acidic to alkaline.
A.Colourlessto pink
B.Yellow to red
C.Red to blue
D.Red to Yellow

10. Iodine Titration
IoDimetry= Direct method
Iodometry=Indirect method

11. •The titration of liberated iodine in chemical reaction is know as:
A. Iodometry
B. Iodinometry
C.Iodonometry
D.Iodimetry
NPC LICENSE PAST QUESTION

12. Types of Non-Aqueous Solvents
Aprotic
Solvent
•CCL4
•Benzene
•Toluene
Protophilic
solvents
•Liq.
Ammonia
•Amines
•Ether
•Ketones
Protogenic
Solvents
•Hydrofluoric
acid
•Acetic acid
•Formic acid
•Sulfuric acid
Amphiprotic
solvents
•Water
•Alcohol
•Acetic acid

13. Precipitation titration
•Mohr’s Method
Indicator: Chromate (@ MC)
Endpoint: brick pptof silver chromate
•Volhard’smethod (Back Titration)
Indicator: Ferric ions (@ VF)
Endpoint: Reddish colour
Fajan’smethod:
Indicator: Fluorescein
Endpoint: Reddish colour

14. Indicators of Complex titration
1.Murexide
2.Solochrometitration
3.Calmagite
4.Pyrocatecholviolet

15. Kjedahalmethod
•Used to determine the nitrogen content is organic and inorganic
substances.
•This method is also used to estimate protein content in food.
The kjedahalmethod is used to determine:
A.Oxygen
B.Sulphur
C.Nitrogen
D.Chlorine
NPC PAST QUESTION

16. Karl Fischer Titration:
•Used to determine quantity of water present in a given analyte.
The Karl Fischer method is used to determine:
A.Oxygen
B.Sulphur
C.Moisture
D.Chlorine

18. •Quick identification of a compound is possible with the help
of………..
A.Mass Spectra
B.NMR Spectra
C.IR Spectra
D.UV Spectra
•The vibrational frequency of Amine………
A.3300-3350
B.1720-1740
C.3400-3700
D.1700-1725
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19. Gas Chromatography Detectors
•Electron Capture Detectors (ECD)
•Flame ionization Detectors (FID)
•Flame Photometric Detectors (FPD)
•Hall electrolytic conductivity Detector
•Nitrogen-phosphorus Detector
•Photo-Ionization Detector (PID)
•Thermal Conductivity Detector (TCD)
@ EFFGHIJKLMNOPQRST
Normal Phase
SP=Polar &
MP= Non-Polar
Reverse Phase
SP=Non-Polar &
MP=Polar

20. •Activation time of TLC Plate is……………
A.120-130 degree for 30 min
B.30-40 degree for 1 hrs
C.200 degree for 3 hrs
D.None
•Which of the following is Not a type of detector used in GC?
A.Electron capture detector
B.Thermal conductivity detector
C.UV visible spectrometric detector
D.Photo ionization detector

21. HPLC DETECTORS
•UV-Visible Spectrometer (most widely used)
•Refractive Index Detector
•Fluorescent Detector
•ConductometricDetector
@ U RFired From Company