pharmaceutical powder dosage form (gasha).pptx

ppt

1. Pharmaceutical powder By Dr. Muhannad O. Taher MSc Pharmaceutics 1 st semester, 1 st stage

2. Powders are mixtures of dry, finely divided drugs and/or chemicals that may be intended for internal or external use. Definition

3. Powders as Dosage From • Because of their greater specific surface area, powders disperse and dissolve more readily than compacted dosage forms. • Children and those adults who experience difficulty in swallowing tablets or capsules may find powders more acceptable.

4. Oral Powder

5. Advantages More stable than liquid More convenient to swallow than tablet or capsules Can be prepared into granules for use in preparing tablets and or reconstituted to liquid form Rapid therapeutic effect due to large surface area Useful for bulky drugs with large dose Disadvantages Unpleasant tasting of drugs It is difficult to protect powders containing hygroscopic, deliquescent or aromatic materials from decomposition. Inaccurate dose measurement of powder drug

6. Types of Powders Divided powders packets cachets Bulk (Undivided) powders dusting powder effervescent powder antacids, laxatives, dietary nutrient supplement s

7. Preparation of Powders 7 Weighing of each ingredient. Reduction of particle size of all ingredients to the same range to prevent stratification. Sieving . Mixing . Packaging .

8. 5 4 Effervescent Powders Definition: Mixture of organic acid and alkali , e ffervesces when subjected to water due to reaction between the acid and the base with evolution of co 2 Examples: Citric or tartaric acids with sodium carbonate or bicarbonate Uses: The liberated carbon dioxide has the following advantages: It masks the bitter taste . It promotes gastric secretions. It acts as a carminative.

9. Effervescent Powders Formulation: Ingredients: drug, citric acid or tartaric acid, sodium bicarbonate. 1- weigh the amount of each ingredients. 2- proper mixing. 3- add the mixture to the glass of water.