PHARMACOKINETIC MODEL

INTRODUCTION, METHODS FOR ANALYSIS OF PHARMACOKINETIC DATA, APPLICATION OF PHARMACOKINETIC MODEL, TYPES OF PHARMACOKINETIC MODEL,PHYSIOLOGICAL MODELS

1. PHARMACOKINETIC MODEL GUIDED BY:- DR.JUBER AKHTAR PRESENTED BY:- VIKAS AAGRAHARI NAUREEN FATIMA 9/23/2019 1

2. CONTENTS- 9/23/2019 2

3. INTRODUCTION 9/23/2019 3

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5. PHARMACOKINETIC MODELS 9/23/2019 5

6. WHY MODEL THE DATA ?  9/23/2019 6

7. APPLICATIONS OF PHARMACOKINETIC MODEL Pharmacokinetic model are useful in-  Characterizing the behaviour of drugs in patients.  Predicting the conc. of drug in various body fluids with any dosage regimen.  Predicting the multiple dose concentration curves from single dose experiment.  Calculating the optimum dosage regimen for individual patients.  Correlating plasma drug concentration with pharmacological response.  Determination of altered ADME level in specific disease condition. Predicting the possibility of drug interaction. 9/23/2019 7

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9. COMPARTMENT MODELS 9/23/2019 9

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12. Depending upon whether the compartment are arranged parallel or in series, compartments models are divided into two categories –  Mammillary model Catenary model  9/23/2019 12

13. MAMMILLARY MODEL 9/23/2019 13

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16. USES OF MAMMILLARY MODEL 9/23/2019 16

17. CATENARY MODEL 9/23/2019 17

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19. APPLICATIONS OF COMPARTMENT MODELLING APPROACH  9/23/2019 19

20. DISADVANTAGE OF COMPARTMENT MODELLING 9/23/2019 20

21. PHYSIOLOGICAL MODELS 9/23/2019 21

22. PHYSIOLOGICAL MODELS 9/23/2019 22

23. Difference between Physiological model and other compartment model 9/23/2019 23

24. DISTRIBUTED PARAMETER MODELS 9/23/2019 24

25. NON COMPARTMENT ANALYSIS 9/23/2019 25

26. REFERENCES 9/23/2019 26

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