PHARMACOLOGICAL ACTION OF CHATURVIDHA RASAYANAS. (DR. PRITI PUSAM)

Pharmacological action of Parada murchit aushadhi i. e. 1. Kharaliya Rasayana 2. Parpati Rasayana, 3. Pottali Rasayana, 4. Kupipakwa Rasayana.

1. VD. PRITI H. PUSAM PG SCHOLAR (RASASHASTRA DEPT.) G.A.C. OSMANABAD “PHARMACOLOGICAL ACTION OF CHATURVIDHA RASAYANA.”

2. INTRODUCTION: Rasaushadhi = Rasa= Parada Aushadhi= formulation अल्पमात्रा उपयोगित्वात अरूचे: अप्रसंगत्वात क्षिप्र आरोग्यदायित्वात अधिको रस: PARADA: “ रसेषु उत्तम:” “सर्वरोगविनाशक:” Heart of Rasashastra Master metal Yogavahi Rasayana Any rasakalpa containing mercury has increased strength of medicine.

3. CLASSIFICATION OF RASAKALPAS: ( PARADA MURCHIT KALPA) As per method of preparation:

4. 1. KHARALIYA RASAYANA: Prepared in crucible hence known as khalviya rasayana. Ex. – Kajjali KAJJALI :- 1. Is an example of sagandha niragni kalpana of kharaliya kalpa. 2. Purified Parada & gandhaka are constantly triturated under pressure at atmospheric temperature. 3. Constant & consistent pressurized triturating of kajjali enhances pharmaco dynamic properties. 4. The process of constant trituration will pack the gandhaka molecule in between layer of parada molecule. therefore sustained release of active molecules take place.

5. CONCEPT:- Most widely and frequently used in therapeutics. Prolong shelf life. Enhance the therapeutic efficacy. Decrease the duration of treatment. Can be administered directly as per required doses. Can be transformed into the form of pills, tablets, capsules etc…

6. 2 . PARPATI RASAYANA द्रुतकज्जलिका मोचापत्रके चिपटीकृता च l स पोट: पर्पटी सैव बलाद्यखिलरोगनुत II र. र. स. ११/७२

7. CONCEPT: Sagandha sagni parada murchit kalpana. Ex. - Rasaparpati Brittle flakes of sulphuric mercurial combination, gray to blackish in color. Kajjali is the base material. Agni sanskara is an important aspect of parpati kalpana Method of preparation: kajjali is placed an iron pan and heated on mild fire till it get semi liquid to liquid consistency , then it is placed on banana leaves and pressed with a flat heavy object after covering with another banana leaf.

8. Parpati- Is potabandha of Parada which control the movement and fragility of Parada. Heat - Heat energy enhance the therapeutic efficacy & emphasizes lightness. Gomaya – Comes from alimentary tract of the cow and have enzymatic activity. Ghee- It has synergistic effect. Patra (kadali or eranda)- Increases potency of drug. Highly rich in chlorophyll which able to neutralize negative effects of free radicals in the body. IMPORTANCE OF PARPATI RASAYANA

9. 3. POTTALI RASAYANA विस्तारितस्या द्रव्यस्य अल्पिभावानं पोट्टमं l पोट्टमंलाति ग्रीह्नाती इति पोट्टलि:

10. DIFFERENT METHODS OF POTTALI PREPARATION:- MODE OF ADMINISTRATION OF POTTALI RASAYANA: POTTALI- Should be rubbed over a scratch stone with Ghrita or Madhu and make paste. IN RASAMRUTA- Rub the pottali with adraka or nagavalli swarasa in sannipata condition. 1.Gandhaka drava paka 2. Putapaka 3.Bhavana vidhi

11. IMPORTANCE OF POTTALI RASAYANA The word pottali means to minimize the shape of drug into a more compact and potent form. Used as emergency & life saving remedy. Method of administration via tongue help in quick absorption. Unique preparation method. Less dose with high potency. Convenience in transportation. Long shelf life.

12. 4. KUPIPAKWA RASAYANA “कुप्याम अग्नीनां पक्वं यद रसायनमं तत कुपिपक्वारसायनं l “

13. DISCRIPTION: This is unique & different method of preparation of preparing bhasma. In a specially built furnace, earthen vessel filled with sand , a coated glass of bottle with mixture is kept. Heat is given from below the ascending temperature for 24 to 72 hours. The desired medicine obtained from neck and bottom of the bottle.

14. IMPORTANCE OF KUPIPAKWA RASAYANA: Best rasayana I t requires minimum dose. Easy for administration. More potent and quicker action. Potency of these drug remain for longer period. Cure even asadhya rogas.

15. CONCLUSION : Parada is yogvahi - thus quick in action. Chemical bond becomes stronger in following order- KAJJALI-PARPARI-POTTALI-KUPIPAKWA RASAYANA. In kajjali preparation- The triturating causes friction, pressure, motion it help to form smallest particle of drug, so bioavailability increases. In parpati rasayana- Due to Agni sanskara emphasizes lightness. In pottali rasayana- technique give compactness to the scattered material. In kupipakwa rasayana- Trituration, heat application ( mrudu-madhya-trivragni ) helps in particle size reduction. Making drug to reach at difficult sites in body. Due to shodhan , maran , mardan , agni sanskar , puta the particle size reduces as to provide better bioavailability & faster absorption . Can reach fast up to utter dhatu i.e. asthi , majja , sukra etc.

16. DISCUSSION: Life saving remedy. Easy to handle. Useful in acute condition. Can use as antibiotics of Ayurveda. Easy administration of medicine. Easy to transport and carry .

17. REFFERENCES Ayurvediya aushadhikarn , Bhag 1 &2, by vd . P.V. Dhamankar & vd . G.V. Puranik , 2 nd edition, Dhutpapeshwar publication. Ayurvediya Rasashastra by dr. Sidhinandan mishra , ISBN:97881-7637-114-8, Chaukhamba Orientalia publication. Shri vagbhatacharya virachit Rasaratnasamuchya by dr Sidhinandan mishra , , Chaukhamba Orientalia publication. Chaturvidha rasayana by dr Raghuveer Chemistry of Kupipakwa rasayanas a review by P.K Sarkar et al, april 2008, vol:No xxvii(4) april , may, june – 2008 Pottali kalpana: a concise & potent pharmaceutical dosage form of indian system of medicine by S.Palbag et al.journal of biological & scintific opinion, vol 1(1)2013 A comprehensive review on parpati kalpa, by D. Shrilakshmi / Int.J.Res . Ayurveda Pharma.6(2), mar- apr 2015 www.wjpr.net Pharmaceutical study of hemagarbha pottali by S. Vedbhushan et al. Int.J.Res . Ayurveda Pharma . , ISSN:2322-0910

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