Pharmacology of drugs used in mania

MR.BESTHA. CHAKRAPANI M.PHARM
ASSOCIATE PROFESSOR
DEPARTMENT OF PHARMACOLOGY
BALAJI COLLEGE OF PHARMACY
ANANTAPURAMU

1. PHARMACOLOGY OF DRUGS USED IN MANIA
MR.BESTHA. CHAKRAPANI M.PHARM
ASSOCIATE PROFESSOR
DEPARTMENT OF PHARMACOLOGY
BALAJI COLLEGE OF PHARMACY
ANANTAPURAMU

2. Lithium is the classic mood stabilizer to
prevent further manic and depressive episodes.
Veerapamil, a calcium-channel blocker, is
useful in the treatment of hypomania

3. MANIA
Mania, also known as manic syndrome, is a
state of abnormally elevated arousal, affect,
and energy level, or "a state of heightened
overall activation with enhanced affective
expression together with lability of affect.

4. • Although mania is often conceived as a
"mirror image" to depression, the heightened
mood can be either euphoric or irritable;
indeed, as the mania intensifies, irritability can
be more pronounced and result in violence, or
anxiety.
MANIA-1

5. Mania is a syndrome with multiple causes.
Although the vast majority of cases occur in
the context of bipolar disorder.
 It is a key component of other psychiatric
disorders (such as schizoaffective disorder
bipolar type) and may also occur secondary to
various general medical conditions, such as
multiple sclerosis; certain medications may
perpetuate a manic state

6. SYMPTOMS
Inflated self-esteem or grandiosity.
 Decreased need for sleep (e.g., feels rested after 3
hours of sleep).
More talkative than usual or pressure to keep talking.
 Flights of ideas or subjective experience that thoughts
are racing.
Increase in goal directed activity, or psychomotor
acceleration.
 Distractibility (too easily drawn to unimportant or
irrelevant external stimuli).
 Excessive involvement in activities with a high
likelihood of painful consequences.(e.g., extravagant
shopping, improbable commercial schemes,
hypersexuality).

8. TREATMENT
Before beginning treatment for mania, careful
differential diagnosis must be performed to rule out
secondary causes.
The acute treatment of a manic episode of bipolar
disorder involves the utilization of either a mood
stabilizer (valproate, lithium, or carbamazepine) or
an atypical antipsychotic (olanzapine, quetiapine,
risperidone, or aripiprazole).

13. TREATMENT-1
•Although hypomanic episodes may respond to
a mood stabilizer alone, full-blown episodes
are treated with an atypical antipsychotic
(often in conjunction with a mood stabilizer, as
these tend to produce the most rapid
improvement)

14. syMpToMs of MANiA
Heightened mood
(either euphoric or irritable);
 Flight of ideas
 Pressure of speech;
 Increased energy,
Decreased need for sleep,
Hyperactivity.

15. HYPERACTIVITY

16. HYPERACTIVITY

17. INFANT HYPERACTIVITY

18. HYPERACTIVITY