Pharmacology Pharmacokinetics – Absorption .pptx

Definition of pharmacokinetics
Definition of absorption
Factor affecting drug absorption
Mechanism of drug absorption
Conclusion

1. Institute Name :- Pandaveswar school of pharmacy Name :- Eshita Bandyopadhyay Roll no :- 38405923016 Subject :- pharmacology 1 ; code :- 418 Semester :- 4 th semester ( CA – 2 ) Topic :- pharmacokinetics – Absorption

2. Index :- Definition of pharmacokinetics Definition of absorption Factor affecting drug absorption Mechanism of drug absorption Conclusion Reference

3. Definition of pharmacokinetics :- pharmacokinetics is a quantitative study of drugs movement in through and out of the body. “ What does body do to the drugs ” It involves four processes. ( ADME ) :- Absorption Distribution Metabolism Excretion Definition of absorption :- In pharmacokinetics, absorption refers to the process by which a drug moves from its site of administration into the blood stream.

4. Factor affecting drug absorption :- Route of administration :- oral , intravenous , intramuscular and transdermal routes affect absorption rate differently. Drug solubility :- lipophilic drugs cross cell membrane easily than hydrophilic drugs. Molecular size :- Smaller molecules generally absorb more quickly. PH and ionization :- The pH of the drug and environment affect solubility and permeability. Blood Flow to the absorption site :- Higher blood flow increases absorption. First pass metabolism :- Drugs take orally may be metabolized by the liver before reaching systematic circulation .

5. Absorption mechanism :- Passive diffusion :- most common, the drug moves from a high to low concentration area. Facilitated diffusion :- uses carrier proteins but no energy. Active Transport :- Requires energy to move drugs against the concentration gradient. Endocytosis :- large molecules may be engulfed by cells.

6. Conclusion :- Absorption is a crucial step in pharmacokinetics that determines a drug efficacy understanding it’s influencing factors helps in optimising drug formulations , improving therapeutic outcomes, and minimising adverse effects .

7. Reference :- “Essentials of medicinal pharmacology ” - K. D. Tripathi www.ncbi.nlm.nih.gov