Photon Vs proton beam therapy

Intensity modulated proton therapy (IMPT)
Photon Vs Proton beam therapy
Dosimetric comparison between Photon and Proton Beam

1. Photon Vs Proton beam therapy Presenter: Dr. Vijay. P. Raturi

2. Radiation technique from 2D-3D era

3. Radiotherapy delivery systems 2D-Conventional (Cobalt teletherapy machine) 3D-Conformal (Linear accelerator) Proton therapy delivery system

4. Change in dosimetry profile from 2D-3D era

5. Dosimetry profile of 3DCRT, IMRT, VMAT, PBT

6. Physical Rationale Protons have different dosimetric characteristics than photons used in conventional radiation therapy. After a short build-up region, conventional radiation shows an exponentially decreasing energy deposition with increasing depth in tissue. In contrast, protons show an increasing energy deposition with penetration distance leading to a maximum (the “Bragg peak”) near the end of range of the proton beam Typical dose distribution as a function of depth for proton beam

7. Clinical Rationale : The rationale for the clinical use of proton beams is the feasibility of delivering higher doses to the tumor, leading to an increased tumor control probability (TCP) Like other highly conformal therapy techniques, proton therapy is of particular interest for those tumors located close to serially organized tissues Irregular shaped lesions near critical structures are well suited for protons. Proton therapy has been applied for the treatment of various disease sites.

8. Key message Intensity modulated proton therapy (IMPT) provide better dosimetry profile in comparison to intensity modulated radiotherapy (IMRT) and volumetric arc radiotherapy (VMAT) Intensity modulated proton therapy (IMPT) has better clinical outcome in term of toxicity profile

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