Phytosomes ppt

phytosomes

1. PHYTOSOMES Presented By, Yogita T. Rayate M.Pharm First Year Pharmaceutics 17-04-2018 1

2. INTRODUCTION- What is Phytosome ?: Phytosomes are novel drug delivery system containing hydrophilic bioactive phytoconstituents of herbs surround and bound by phospholipids . Phytomedicines are complex chemical mixtures prepared from plants. Water soluble phytoconstituents ( flavonoids ) are poorly absorbed. 17-04-2018 2

3. Reasons are- 1. Multiple-ring large size molecules - can not be absorbed by simple diffusion. 2. Poor miscibility. Water-soluble phytoconstituents can be converted into lipid-compatible molecular complexes. Phytosomes are more bioavailable . Phytosomes are lipid-compatible molecular complexes. 17-04-2018 3

4. Physical properties : It is lipophilic substance Freely soluble in nonpolar solvent . Moderately soluble in fats . Insoluble in water 17-04-2018 4

5. MERITS- 1. There is a enhancement of the bioavaibility of botanical extract due to their complexation with phospholipid and improved absorption in the intestinal tract. 2. The formulation of phytosomes is safe and the components have all been approved for pharmaceutical s and cosmetic use. 3. Phytosomes shows better stability profile because chemical bond are formed between phosphotidylcholine molecules and phytoconstituents . 17-04-2018 5

6. 4.This technology offers cost effective delivery of phytoconstituents . 5.They can be also used for enhanced permeation of drug through skin for transdermal and dermal delivery. 6. Phytosomes are also superior to liposomes in the skin care products. 7.They can be widely used in the cosmetics due to their improved skin penetration and high lipid profile. 17-04-2018 6

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10. Common stages of preparation Phospholipids Solution of phospholipidsin organic solvent with drug extract Drying Formation of thin film 17-04-2018 10

11. Hydration Formation of phytosomal suspension 17-04-2018 11

12. Evaluation- 1.Entrapment efficiency 2.Vesicle size 3.Surface tension activity measurement 4.Spectroscopic evaluation 17-04-2018 12

13. Applications- Enhancing bioavailability Antioxidant properties Hepato protective Transdermal application Cancer tretment 17-04-2018 13

14. References- 1.Chivte Prajkta ,A review on therapeutic applications of phytosomes,Journal of drug delivery &therapeutics, 2017;(5):17-21 2.Joseph Kareparamban , pravin Nikam,Phytosome -A novel revoluation in herbal drugs,IJRPC 2012,2(2) 17-04-2018 14

15. THANK YOU 17-04-2018 15