Platelet Indices.pptx

HEMATOLOGY

1. Platelet Indices Dr. Umme Habiba

2. Histogram for Blood Cell Counts

3. Interpretation of normal platelet histogram: Normal platelet histogram is left skewed (arrow, A), MPV calculation (B), PDW calculation (C), thrombocytosis vs normal curve (D), thrombocytopenia vs normal curve (E), PL flag (F) and PU flag (G ).

4. Plateletcrit PCT Volume of platelets expressed as a % of total blood volume. Formula: PCT = platelet count × MPV / 10,000 Optimal Result: 0.22 - 0.24 %. Low Plateletcrit indicates true thrombocytopenia.

5. PDW

6. PDW PDW means Platelet Distribution Width i.e. how widely are platelets dispersed depending upon variation in their size. It ranges from ( 25-65 ). A high PDW means there is a great variation in size, which may be associated with vascular (blood vessel) disease or certain cancers.

7. Platelet Large Cell Ratio

8. P-LCR: P-LCR  means  Platelet large cell   ratio  and it’s calculated in automated blood analyzers using this formula: P-LCR = P-LCC/PLT . PLT = Total Platelets Count. P-LCC = platelets larger than 12 fl and smaller than 30fl .

9. The platelet–large cell ratio (P-LCR) is an indicator of circulating larger platelets (>12 fl ) and the best tool to assess megakaryocyte activity Increased percentage of large platelets (P-LCR) is observed in patients with Hyperlipidaemia and suggest possible risk of thrombosis. An increase in P-LCR + MPV + PDW has been observed in autoimmune thrombocytopenic purpura .

10. MPV MPV means the average volume of counted platelets. It is analogous to the erythrocyte MCV. MPV ( fL ) = PCT% / PLT count Reference range= 8-12 fL

11. Clinical Significance High MPV Thrombocytopenia . Myeloproliferative disorders Preeclampsia Heart disease Diabetes Hemolytic  anemia Low MPV Certain cancers Drug-induced Aplastic anemia Autoimmune diseases Bacterial  or  viral infections Genetic conditions Alcohol use disorder (AUD)

12. THANKS