Pleno Pakar 8 Sept 2025. sidang pleno ke 8

pleno

1. Pleno Pakar FKG

2. Antibiotik ≠ ANTIMIKROBA P embasmi mikroba, khususnya mikroba yang merugikan manusia. Mikroba terbatas pada jasad renik yang tidak termasuk kelompok parasit Z at yang dihasilkan oleh suau mikroba, terutama fungi, yang dapat menghambat atau dapat membasmi mikroba jenis lain. (Farmakologi & Terapi FK UI, 2012) Antibiotik Antimikroba Seminar Ilmiah .Updates On Management Daily Practice Case 18-19 februari 2023

3. Obat pembasmi mikroba memiliki sifat toksisitas selektif setinggi mungkin artinya...... ? Sangat toksik untuk mikroba Relatif tidak toksik untuk hospes / manusia Seminar Ilmiah .Updates On Management Daily Practice Case 18-19 februari 2023

4. P emberian antibiotik yang rasional SOP INFEKSI ANTIBIOTIKA DOSIS & CARA EVALUASI KULTUR POLA KEPEKAAN EDUCATED GUESS THERAPY Seminar Ilmiah . Updates On Management Daily Practice Case 18-19 februari 2023

5. Antimicrobial Policies: Classification First-choice antimicrobials ( non-restricted use ) Used by all prescribers without approval by senior prescribers Safe, effective, reasonably priced antimicrobials Restricted use For more serious clinical conditions under certain conditions Less safe, more expensive, newer antimicrobials Conditions could include the following: Specific infections known to be sensitive to the antimicrobial medicine after culture and sensitivity testing Empirical treatment for suspected life-threatening infections pending the result of culture and sensitivity Counter-signature by a senior physician approved by DTC Reserve antimicrobials ( very restricted use ) For life-threatening infections known to be resistant to other antimicrobials Approval needed by the DTC or microbiologist Seminar Ilmiah . Updates On Management Daily Practice Case 18-19 februari 2023

6. Factors to consider when choosing Antibiotic Drug issues Efficacy Tolerability Safety Dosage Cost Patient issues Etiology Pola Kepekaan Spectrum Co-prescription. Co-morbidity. Compliance. BENEFITS efficacy RISKS safety Seminar Ilmiah . Updates On Management Daily Practice Case 18-19 februari 2023

7. Dosage regimen Concentration vs time in plasma Concentration vs time in site of infection Antibiotic effect vs time Concentration vs time in tissue and other body fluids Pharmacologic or toxicologic effect Relationship between PK and PD pharmacodynamics pharmacokinetics Absorption Protein binding Distribution Biotransformation Excretion Craig WA. Pharmacokinetic/pharmacodynamic parameters: Rationale for antibacterial dosing of mice and men. Clin Infect Dis. 26:1–12,1998 Seminar Ilmiah . Updates On Management Daily Practice Case 18-19 februari 2023

8. Penggolongan berdasarkan Kemampuan Antibakteri terhadap Bakteri Gram- positif dan Gram- negatif Gram-Positif Daptomisin; Klindamisin; Linkomisin; Linezolid; Makrolid (azitromisin, eritromisin, dan klaritromisin); Penisilin (benzatin benzil penisilin, dikloksasilin, fenoksimetil penisilin, kloksasilin, prokain benzil penisilin, nafsilin, oksasilin); Sefalosporin generasi pertama (sefadroksil, sefaleksin, sefalotin, sefazolin); T erasiklin dan diksisiklin; Teikoplanin; Vankomisin Gram-Positif & Gram-Negatif Gram-Negatif Aztreonam; Aminoglikosida; Kolistin; Polimiksin B; Sefalosporin generasi kedua (sefaklor, sefoksitin, cefotetan, sefuroksim) Ampisilin, ampisilin-sulbaktam, amoksisilin, amoksisilin-asam klavulanat; Fluorokuinolon ( levofloksasin , moksifloksasin,siprofloksasin ); Fosfomisin , Karbapenem ( dosipenem , imipenem , meropenem , ertapenem ); Klorafenikol , Ko-trimoksazol ; nitrofurantoin; Piperasilin , piperasilin-tazobaktam , dan tikarsilin ( baik untuk Pseudomonas aeruginosa, Streptococcus dan Enterococcus ); Sefalosporin generasi ketigas ( Sefdinir , sefiksim , sefoperazon , sefotaksim , sefpodoksim , seftazidim , seftriakson ) Sefepim , Tigersiklin ( kurang aktif untuk Pseudomonas dan Proteus ) Antibiotik Antibiotik Antibiotik Seminar Ilmiah . Updates On Management Daily Practice Case 18-19 februari 2023

9. Cell Wall Cell membrane Protein synthesis Nucleic Acid Synthesis Antimetabolites Mekanisme Kerja Antibiotik Seminar Ilmiah . Updates On Management Daily Practice Case 18-19 februari 2023

10. Seminar Ilmiah . Updates On Management Daily Practice Case 18-19 februari 2023