PLEOCYTOSIS

PREPARED BY: MUHAMMAD ARIFF B. MAHDZUB

BACHELOR MEDICINE AND SURGERY (MBBS)
UNIVERSITY COLLEGE SHAHPUTRA, KUANTAN

1. 1 CEREBROSPINAL FLUID PLEOCYTOSIS PROBLEM BASED LEARNING (PBL) PREPARED BY: MUHAMMAD ARIFF B. MAHDZUB BACHELOR MEDICINE AND SURGERY (MBBS) UNIVERSITY COLLEGE SHAHPUTRA, KUANTAN

2. Definition Pleocytosis defined as an increased cell count , usually increase in white blood cell ( wbc ) count in cerebrospinal fluid ( csf ) BUT, pleocytosis due to increased of csf protein and csf glucose also happen in some cases Increased in wbc can be either elevated of polymorphonuclear leucocytes or mononuclear leucocytes

3. Increased of mononuclear cell due to virus Increased of polymorphonuclear cell due to bacteria

4. Increased WBC in the CSF This happen when WBC count greater than 5/ mmcubic Giving clue to the clinicians it is due to invasion bacterias or viruses This can be due to meningitis,encaphalitis

5. Abnormalities of CSF glucose High traces of glucose in the CSF may be a reflection of higher blood glucose ( hyperglycemia ) Lower levels of glucose in the CSF may indicate increased glucose use Lower CSF glucose levels are often found in conjunction with infections of the central nervous system.

6. Abnormalities of CSF protein It can be caused by increased permeability of the blood-brain barrier H igh levels of protein in the CSF may indicate that blood is spilling into the CSF Diseases in which there is increased CSF protein include hydrocephalus, meningitis, Guillain-Barre syndrome, subarachnoid hemorrhage

7. Conclusion Result of a CSF examination are used to further narrow the diagnostic possibilities The important clues include whether the clinical conditions is = acute/chronic = infectious/ noninfectious = predominantly lymphocytic or neutrophilic